Journal article
New insights into calcifying pseudoneoplasm of the neuraxis (CAPNON): a 20‐year radiological–pathological study of 37 cases
Histopathology, Vol.76(7), pp.1056-1070
06/2020
DOI: 10.1111/his.14066
PMID: 31955449
Abstract
Aims
Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare entity that can occur anywhere within the central nervous system. Histologically, CAPNON has been characterised as a benign, calcified, fibro‐osseous lesion with a characteristic chondromyxoid fibrillary matrix with dense calcification and varying degrees of spindle, epithelioid, fibrous, meningothelial and giant cells. The underlying aetiology of CAPNON is controversial and incompletely understood. The aim of this study was to perform a comprehensive radiological and histological review to further characterise this entity.
Methods and results
In this article, we review our institutional 20‐year experience including 37 cases of CAPNON with detailed pathological analysis, evaluation of concurrent lesions, correlation with radiological imaging, and critical review of the literature. The classic histological finding of chondromyxoid matrix was present in one‐third of cases. Underlying or dual pathologies were frequent, and included diverse underlying conditions. Radiologically, dense calcification and dural attachment were the most common features. Enhancement was often low, but was more prominent in the setting of inflammatory changes, aggressive growth, and dual pathology.
Conclusion
Our results suggest that CAPNON represents a spectrum of reactive processes that can arise in association with diverse underlying pathologies, including inflammatory, degenerative, vascular and neoplastic lesions.
Details
- Title: Subtitle
- New insights into calcifying pseudoneoplasm of the neuraxis (CAPNON): a 20‐year radiological–pathological study of 37 cases
- Creators
- Mai‐Lan Ho - Nationwide Children's HospitalKathryn L Eschbacher - Mayo Clinic in FloridaMichael A Paolini - Mayo ClinicAditya Raghunathan - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Histopathology, Vol.76(7), pp.1056-1070
- DOI
- 10.1111/his.14066
- PMID
- 31955449
- ISSN
- 0309-0167
- eISSN
- 1365-2559
- Number of pages
- 15
- Grant note
- Mayo Clinic
- Language
- English
- Date published
- 06/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984276452902771
Metrics
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