New insights into vinculin function and regulation

Xiao Peng; Elke S Nelson; Jessica L Maiers; Kris A DeMali

doi:10.1016/B978-0-12-386043-9.00005-0

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New insights into vinculin function and regulation

Journal article

Peer reviewed

New insights into vinculin function and regulation

Xiao Peng, Elke S Nelson, Jessica L Maiers and Kris A DeMali

International review of cell and molecular biology, Vol.287, pp.191-231

2011

DOI: 10.1016/B978-0-12-386043-9.00005-0

PMCID: PMC4426885

PMID: 21414589

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Abstract

Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. Much is now known regarding the role of vinculin in governing cell-matrix adhesion. In the past decade that the crystal structure of vinculin and the molecular details for how vinculin regulates adhesion events have emerged. The recent data suggests a critical function for vinculin in regulating integrin clustering, force generation, and strength of adhesion. In addition to an important role in cell-matrix adhesion, vinculin is also emerging as a regulator of apoptosis, Shigella entry into host cells, and cadherin-based cell-cell adhesion. A close inspection of this work reveals that there are similarities between vinculin's role in focal adhesions and these processes and also some intriguing differences.

Cadherins - metabolism

Humans

Actins - metabolism

Vinculin - metabolism

Extracellular Matrix - metabolism

Models, Molecular

Talin - metabolism

Integrins - metabolism

Adherens Junctions - metabolism

Cell Movement - physiology

Vinculin - chemistry

Actin-Related Protein 2-3 Complex - metabolism

Animals

Vinculin - genetics

Cell Adhesion - physiology

Cardiomyopathies - metabolism

Focal Adhesions - metabolism

Cytoskeleton - metabolism

Protein Conformation

Apoptosis - physiology

Details

Title: Subtitle: New insights into vinculin function and regulation
Creators: Xiao Peng - Department of Biochemistry, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, USA
Elke S Nelson
Jessica L Maiers
Kris A DeMali
Resource Type: Journal article
Publication Details: International review of cell and molecular biology, Vol.287, pp.191-231
DOI: 10.1016/B978-0-12-386043-9.00005-0
PMID: 21414589
PMCID: PMC4426885
NLM abbreviation: Int Rev Cell Mol Biol
ISSN: 1937-6448
Publisher: Netherlands
Grant note: 5T32GM073610 / NIGMS NIH HHS 1K01CA111818 / NCI NIH HHS T32 GM073610 / NIGMS NIH HHS K01 CA111818 / NCI NIH HHS
Language: English
Date published: 2011
Academic Unit: Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984024526002771

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