Journal article
New nitrogen-containing bromophenols from the marine red alga Rhodomela confervoides and their radical scavenging activity
Food chemistry, Vol.135(3), pp.868-872
12/01/2012
DOI: 10.1016/j.foodchem.2012.05.117
PMID: 22953798
Abstract
► Five new nitrogen-containing bromophenols were isolated from the marine red alga Rhodomela confervoides. ► The isolated bromophenols displayed potent radical scavenging activity against DPPH and ABTS radicals. ► These bromophenols may have potential application in food and/or pharmaceutical fields as natural antioxidants. In addition to nine known bromophenol derivatives, five new nitrogen-containing bromophenols were isolated from an ethyl acetate extract of the marine red alga Rhodomela confervoides. By using spectroscopic methods, the structures of the new compounds were identified as 3-(2,3-dibromo-4,5-dihydroxybenzyl)pyrrolidine-2,5-dione (1), methyl 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoate (2), 4-(2,3-dibromo-4,5-dihydroxybenzylamino)-4-oxobutanoic acid (3), 3-bromo-5-hydroxy-4-methoxybenzamide (4), and 2-(3-bromo-5-hydroxy-4-methoxyphenyl)acetamide (5). All of these bromophenols showed potent scavenging activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals, with IC50 values ranging from 5.22 to 23.60μM. These compounds also displayed moderate activity against ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals, with Trolox Equivalent Antioxidant Capacity values (TEAC) ranging from 2.11 to 3.58mM. The results obtained in this study demonstrate that the bromophenols obtained from R. confervoides may have potential application in food and/or pharmaceutical fields as natural antioxidants.
Details
- Title: Subtitle
- New nitrogen-containing bromophenols from the marine red alga Rhodomela confervoides and their radical scavenging activity
- Creators
- Ke Li - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR ChinaXiao-Ming Li - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR ChinaJames B Gloer - Department of Chemistry, University of Iowa, Iowa City, IA 52242, United StatesBin-Gui Wang - Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
- Resource Type
- Journal article
- Publication Details
- Food chemistry, Vol.135(3), pp.868-872
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.foodchem.2012.05.117
- PMID
- 22953798
- ISSN
- 0308-8146
- eISSN
- 1873-7072
- Grant note
- DOI: 10.13039/501100001809, name: the National Natural Science Foundation of China, award: 30530080; name: National Marine 863 Project, award: 2007AA09Z443; name: the Department of Science and Technology of Shandong Province, award: 2006GG2205023
- Language
- English
- Date published
- 12/01/2012
- Academic Unit
- Chemistry
- Record Identifier
- 9983985862502771
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