New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study

Seyda Baydogan; Chirayu Mohindroo; Merve Hasanov; Maria F. Montiel; Pompeyo Quesada; Irina M. Cazacu; Adrianna A. Luzuriaga Chavez; Maureen E. Mork; Wenli Dong; Lei Feng; Y. Nancy You; Banu Arun; Eduardo Vilar; Powel Brown; Matthew H. G. Katz; Suresh T. Chari; Anirban Maitra; Eric P. Tamm; Michael P. Kim; Manoop S. Bhutani; Florencia McAllister

doi:10.1097/eus.0000000000000057

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New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study

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New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study

Seyda Baydogan, Chirayu Mohindroo, Merve Hasanov, Maria F. Montiel, Pompeyo Quesada, Irina M. Cazacu, Adrianna A. Luzuriaga Chavez, Maureen E. Mork, Wenli Dong, Lei Feng, …

Endoscopic ultrasound, Vol.13(2), pp.83-88

03/01/2024

DOI: 10.1097/eus.0000000000000057

PMID: 38947744

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Abstract

Background and Objectives: Pancreatic cancer (PC) is the third cause of cancer-related deaths. Early detection and interception of premalignant pancreatic lesions represent a promising strategy to improve outcomes. We evaluated risk factors of focal pancreatic lesions (FPLs) in asymptomatic individuals at hereditary high risk for PC. Methods: This is an observational single-institution cohort study conducted over a period of 5 years. Surveillance was performed through imaging studies (EUS or magnetic resonance imaging/magnetic resonance cholangiopancreatography) and serum biomarkers. We collected demographic characteristics and used univariate and multivariate logistic regression models to evaluate associations between potential risk factors and odd ratios (ORs) for FPL development. Results: A total of 205 patients completed baseline screening. Patients were followed up to 53 months. We detected FPL in 37 patients (18%) at baseline; 2 patients had lesions progression during follow-up period, 1 of them to PC. Furthermore, 13 patients developed new FPLs during the follow-up period. Univariate and multivariate analyses revealed that new-onset diabetes (NOD) is strongly associated with the presence of FPL (OR, 10.94 [95% confidence interval, 3.01-51.79; P < 0.001]; OR, 9.98 [95% confidence interval, 2.15-46.33; P = 0.003]). Follow-up data analysis revealed that NOD is also predictive of lesions progression or development of new lesions during screening (26.7% vs. 2.6%; P = 0.005). Conclusions: In a PC high-risk cohort, NOD is significantly associated with presence of FPL at baseline and predictive of lesions progression or new lesions during surveillance.

Gastroenterology & Hepatology

Life Sciences & Biomedicine

Science & Technology

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Title: Subtitle: New-onset diabetes is a predictive risk factor for pancreatic lesions in high-risk individuals: An observational cohort study
Creators: Seyda Baydogan - The University of Texas MD Anderson Cancer Center
Chirayu Mohindroo - The University of Texas MD Anderson Cancer Center
Merve Hasanov - The University of Texas MD Anderson Cancer Center
Maria F. Montiel - The University of Texas MD Anderson Cancer Center
Pompeyo Quesada - The University of Texas MD Anderson Cancer Center
Irina M. Cazacu - The University of Texas MD Anderson Cancer Center
Adrianna A. Luzuriaga Chavez - The University of Texas MD Anderson Cancer Center
Maureen E. Mork - The University of Texas MD Anderson Cancer Center
Wenli Dong - The University of Texas MD Anderson Cancer Center
Lei Feng - The University of Texas MD Anderson Cancer Center
Y. Nancy You - The University of Texas MD Anderson Cancer Center
Banu Arun - The University of Texas MD Anderson Cancer Center
Eduardo Vilar - The University of Texas MD Anderson Cancer Center
Powel Brown - The University of Texas MD Anderson Cancer Center
Matthew H. G. Katz - The University of Texas MD Anderson Cancer Center
Suresh T. Chari - The University of Texas MD Anderson Cancer Center
Anirban Maitra - The University of Texas MD Anderson Cancer Center
Eric P. Tamm - The University of Texas MD Anderson Cancer Center
Michael P. Kim - The University of Texas MD Anderson Cancer Center
Manoop S. Bhutani - The University of Texas MD Anderson Cancer Center
Florencia McAllister - The University of Texas MD Anderson Cancer Center
Resource Type: Journal article
Publication Details: Endoscopic ultrasound, Vol.13(2), pp.83-88
DOI: 10.1097/eus.0000000000000057
PMID: 38947744
ISSN: 2303-9027
eISSN: 2226-7190
Publisher: Lippincott Williams & Wilkins
Number of pages: 6
Grant note: Walter H Wriston Distinguished Professor for Pancreatic Cancer Research Cosmos Wisdom Biotechnology and Thrive Earlier Detection, an Exact Sciences Company
Language: English
Date published: 03/01/2024
Academic Unit: Internal Medicine
Record Identifier: 9985178657702771

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