Journal article
New onset diabetes predicts clinical outcomes in patients with pancreatic adenocarcinoma
Journal of gastrointestinal oncology, Vol.16(1), pp.226-233
02/28/2025
DOI: 10.21037/jgo-24-570
PMID: 40115918
Abstract
Background: One percent of pancreatic adenocarcinoma (PDAC) patients are diagnosed with new onset diabetes (NOD) over the age of 50 years within 3 years. Therefore, NOD is a major factor for early diagnosis of PDAC. Research has focused on understanding the differences between NOD and type 2 diabetes, particularly in relation to PDAC. However, conflicting data exists regarding their impact on survival outcomes in PDAC patients. We performed this multi-center study to assess the prevalence and influence of NOD on clinical outcomes in patients with PDAC within a community-based hospital system. Methods: We conducted a retrospective cohort study of 138 patients with biopsy-proven PDAC with localized/borderline disease (n=70), and metastatic disease (n=68) at three institutions from 2014 to 2021. NOD group consisted of pts diagnosed with diabetes [hemoglobin A1c (HbA1c) >6.5%] or pre-diabetes (HbA1c 5.7-6.4%) within the 3 years prior to PDAC diagnosis. Primary aim of the study was to determine the impact of NOD on clinical outcomes. Results: A total of 138 patients were included in the study, from which 30 met the criteria for NOD. No significant differences were noted in the demographic and clinical characteristics comparing patients based on NOD history. Comparing survival outcomes, NOD group was associated with worse overall survival (OS) in both the metastatic cohort [n=68, progression-free survival (PFS) 4.6 vs. 7.1 months, P=0.07; OS 7.1 vs. 13.2 months, P=0.01) and the resected cohort (n=40, PFS 8.4 vs. 19.3 months, P=0.04; OS 24.5 vs. 42.3 months, P=0.04). In multivariate analysis, the impact of NOD remained significant for OS and PFS in the resected cohort. Identifying common features amongst the NOD group, we found the entire cohort had a significant reduction in individual body mass index (BMI) 1 year prior to the NOD diagnosis (P=0.006). Conclusions: NOD is associated with worse survival outcomes in patients with metastatic and resected PDAC. Reduction of BMI prior to diagnosis of NOD, warrants further investigation to be incorporated into the PDAC screening paradigm.
Details
- Title: Subtitle
- New onset diabetes predicts clinical outcomes in patients with pancreatic adenocarcinoma
- Creators
- Chirayu Mohindroo - Sinai HospitalPaul S. Dy - Sinai HospitalSuraj P. Hande - Sinai HospitalChristopher R. D'Adamo - University of Maryland, BaltimoreArun Mavanur - Johns Hopkins HospitalAsha Thomas - Sinai HospitalFlorencia Mcallister - The University of Texas MD Anderson Cancer CenterAna De Jesus-Acosta - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Journal of gastrointestinal oncology, Vol.16(1), pp.226-233
- DOI
- 10.21037/jgo-24-570
- PMID
- 40115918
- NLM abbreviation
- J Gastrointest Oncol
- ISSN
- 2078-6891
- eISSN
- 2219-679X
- Publisher
- AME PUBLISHING COMPANY
- Number of pages
- 10
- Language
- English
- Date published
- 02/28/2025
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985177931702771
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