Journal article
New paradigms of urinary tract infections: Implications for patient management
Indian journal of urology, Vol.28(2), pp.154-158
01/01/2012
DOI: 10.4103/0970-1591.98455
PMCID: PMC3424889
PMID: 22919128
Abstract
Urinary tract infections (UTIs) represent one of the most commonly acquired diseases among the general population as well as hospital in-patients, yet remain difficult to effectively and consistently treat. High rates of recurrence, anatomic abnormalities, and functional disturbances of the urinary tract all contribute to the difficulty in management of these infections. However, recent advances reveal important molecular and genetic factors that contribute to bacterial invasion and persistence in the urinary tract, particularly for the most common causative agent, uropathogenic
Escherichia coli
. Recent studies using animal models of experimental UTIs have recently provided mechanistic insight into the clinical observations that question the effectiveness of antibiotic therapy in treatment. Ultimately, continuing research will be necessary to identify the best targets for effective treatment of this costly and widespread infectious disease.
Details
- Title: Subtitle
- New paradigms of urinary tract infections: Implications for patient management
- Creators
- Dennis J. Horvath - Nationwide Children's HospitalShareef M. Dabdoub - Nationwide Children's HospitalBirong Li - Nationwide Children's HospitalBrian A. VanderBrink - Nationwide Children's HospitalSheryl S. Justice - Nationwide Children's Hospital
- Resource Type
- Journal article
- Publication Details
- Indian journal of urology, Vol.28(2), pp.154-158
- DOI
- 10.4103/0970-1591.98455
- PMID
- 22919128
- PMCID
- PMC3424889
- NLM abbreviation
- Indian J Urol
- ISSN
- 0970-1591
- eISSN
- 1998-3824
- Publisher
- Medknow Publications & Media Pvt Ltd
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Dental Research; Periodontics
- Record Identifier
- 9984367655202771
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