New prevalence estimate of TT virus (TTV) infection in low- and high-risk population from São Paulo, Brazil

Leda Bassit; Kioko Takei; Sumie HOSHINO-SHIMIZU; Anna S. Nishiya; Ester C. Sabino; Rogério P. Bassitt; Roberto Focaccia; Élbio D'AMICO; Dalton F. Chamone; Gabriela RIBEIRO-DOS-SANTOS

doi:10.1590/S0036-46652002000400010

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New prevalence estimate of TT virus (TTV) infection in low- and high-risk population from São Paulo, Brazil

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New prevalence estimate of TT virus (TTV) infection in low- and high-risk population from São Paulo, Brazil

Leda Bassit, Kioko Takei, Sumie HOSHINO-SHIMIZU, Anna S. Nishiya, Ester C. Sabino, Rogério P. Bassitt, Roberto Focaccia, Élbio D'AMICO, Dalton F. Chamone and Gabriela RIBEIRO-DOS-SANTOS

Revista do Instituto de Medicina Tropical de São Paulo, Vol.44(4), pp.233-234

07/01/2002

DOI: 10.1590/S0036-46652002000400010

PMID: 12219117

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Abstract

The prevalence of TT virus (TTV) infection was investigated by Polymerase Chain Reaction (PCR) in low- (blood donors and healthy children/adolescents) and high-risk (hemophiliacs) groups from São Paulo, Brazil. Primers based on the untranslated region (UTR) of the viral genome proved to be much more ubiquitous, leading to much higher frequencies for both groups ( > or = 81%) than the earlier N22-PCR directed to the open reading frame 1 (blood donors, 5.5%, and hemophiliacs, 42.3%). The UTR-PCR also revealed an interesting profile for healthy children/adolescents: very high prevalence at the early years and significant decrease in male teenagers. The N22-PCR, in turn, demonstrated higher frequency in hemophiliacs treated with fresh blood products (58%), than in those treated with virus-inactivated clotting factors (9.4%) and blood donors (5.5%).

TROPICAL MEDICINE

Details

Title: Subtitle: New prevalence estimate of TT virus (TTV) infection in low- and high-risk population from São Paulo, Brazil
Creators: Leda Bassit - Fundação Pró-Sangue Hemocentro de São Paulo
Kioko Takei - Universidade de São Paulo
Sumie HOSHINO-SHIMIZU - Universidade de São Paulo
Anna S. Nishiya - Fundação Pró-Sangue Hemocentro de São Paulo
Ester C. Sabino - Fundação Pró-Sangue Hemocentro de São Paulo
Rogério P. Bassitt - Fundação Pró-Sangue Hemocentro de São Paulo
Roberto Focaccia - Instituto de Infectologia Emílio Ribas
Élbio D'AMICO - Fundação Pró-Sangue Hemocentro de São Paulo
Dalton F. Chamone - Fundação Pró-Sangue Hemocentro de São Paulo
Gabriela RIBEIRO-DOS-SANTOS - Fundação Pró-Sangue Hemocentro de São Paulo
Resource Type: Journal article
Publication Details: Revista do Instituto de Medicina Tropical de São Paulo, Vol.44(4), pp.233-234
DOI: 10.1590/S0036-46652002000400010
PMID: 12219117
NLM abbreviation: Rev Inst Med Trop Sao Paulo
ISSN: 1678-9946
eISSN: 0036-4665
Publisher: Instituto de Medicina Tropical
Number of pages: 2
Alternative title: Nova estimativa da prevalência da infecção pelo vírus "TT" (TTV) em populações de baixo e alto risco de São Paulo, Brasil
Language: English
Date published: 07/01/2002
Academic Unit: Internal Medicine
Record Identifier: 9984843606702771

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