Journal article
New roles for mononuclear phagocytes in cancer biology
Journal of pediatric hematology/oncology, Vol.30(8), pp.584-591
08/2008
DOI: 10.1097/MPH.0b013e31816e2358
PMID: 18799934
Abstract
The primary focus in the pathogenesis and treatment of human malignancies has been the tumor cell. However, the biologic properties of a malignancy are not all intrinsically determined. Interactions between heterogeneous cell populations influence the growth and survival of both normal and malignant cells. Studies defining the origin of endothelial cells involved in tumor angiogenesis first demonstrated the contributions of normal cellular environment. Recently, the mononuclear phagocyte lineage has been found to have biologically and clinically significant tumor enhancing and tumor suppressive effects. This article reviews the multiple roles of mononuclear phagocytes in cancer biology. A companion manuscript (J Pediatr Hematol Oncol. 2008, in press) describes the targeting of these cells for therapeutic benefit. Incorporating these strategies into future childhood cancer protocols could be an innovative approach for improving patient outcome.
Details
- Title: Subtitle
- New roles for mononuclear phagocytes in cancer biology
- Creators
- Paul T Jubinsky - Pediatric Hematology/Oncology and Developmental and Molecular Biology, Albert Einstein College of Medicine and Children's Hospital, Montefiore, Bronx, NY 10461, USA. pjubinsk@aecom.yu.eduDavid S DickensMary K Short
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric hematology/oncology, Vol.30(8), pp.584-591
- DOI
- 10.1097/MPH.0b013e31816e2358
- PMID
- 18799934
- ISSN
- 1077-4114
- eISSN
- 1536-3678
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093220802771
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