New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease

Young-Cho Kim; Stephanie Alberico; Eric Emmons; Nandakumar Narayanan

doi:10.1007/s11515-015-1360-4

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New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease

Journal article

Peer reviewed

New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease

Young-Cho Kim, Stephanie Alberico, Eric Emmons and Nandakumar Narayanan

Frontiers in biology, Vol.10(3), pp.230-238

06/2015

DOI: 10.1007/s11515-015-1360-4

PMCID: PMC5340264

PMID: 28280503

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https://www.ncbi.nlm.nih.gov/pmc/articles/5340264View

Open Access

Abstract

The neurotransmitter dopamine acts via two major classes of receptors, D1-type and D2-type. D1 receptors are highly expressed in the striatum and can also be found in the cerebral cortex. Here we review the role of D1 dopamine signaling in two major domains: L-DOPA-induced dyskinesias in Parkinson’s disease and cognition in neuropsychiatric disorders. While there are many drugs targeting D2-type receptors, there are no drugs that specifically target D1 receptors. It has been difficult to use selective D1-receptor agonists for clinical applications due to issues with bioavailability, binding affinity, pharmacological kinetics, and side effects. We propose potential therapies that selectively modulate D1 dopamine signaling by targeting second messengers downstream of D1 receptors, allosteric modulators, or by making targeted modifications to D1-receptor machinery. The development of therapies specific to D1-receptor signaling could be a new frontier in the treatment of neurological and psychiatric disorders.

Life Sciences

Biochemistry, general

Genetics and Population Dynamics

D1DR

cognition

Proteomics

Neurobiology

Developmental Biology

dyskinesia

dopamine D1 receptor

Cell Biology

Details

Title: Subtitle: New therapeutic strategies targeting D1-type dopamine receptors for neuropsychiatric disease
Creators: Young-Cho Kim - Department of Neurology University of Iowa Iowa City IA 52242 USA
Stephanie Alberico - Department of Neurology University of Iowa Iowa City IA 52242 USA
Eric Emmons - Department of Neurology University of Iowa Iowa City IA 52242 USA
Nandakumar Narayanan - Aging Mind and Brain Initiative, Carver College of Medicine University of Iowa Iowa City IA 52242 USA
Resource Type: Journal article
Publication Details: Frontiers in biology, Vol.10(3), pp.230-238
DOI: 10.1007/s11515-015-1360-4
PMID: 28280503
PMCID: PMC5340264
NLM abbreviation: Front Biol (Beijing)
ISSN: 1674-7984
eISSN: 1674-7992
Publisher: Higher Education Press; Beijing
Language: English
Date published: 06/2015
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984014022402771

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