New wrinkles in lipoprotein lipase biology

Brandon S J Davies; Anne P Beigneux; Loren G Fong; Stephen G Young

doi:10.1097/MOL.0b013e32834d0b33

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New wrinkles in lipoprotein lipase biology

Journal article

Peer reviewed

New wrinkles in lipoprotein lipase biology

Brandon S J Davies, Anne P Beigneux, Loren G Fong and Stephen G Young

Current opinion in lipidology, Vol.23(1), pp.35-42

02/2012

DOI: 10.1097/MOL.0b013e32834d0b33

PMCID: PMC3383841

PMID: 22123668

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Abstract

We summarize recent progress on GPIHBP1, a molecule that transports lipoprotein lipase (LPL) to the capillary lumen, and discuss several newly studied molecules that appear important for the regulation of LPL activity. LPL, the enzyme responsible for the lipolytic processing of triglyceride-rich lipoproteins, interacts with multiple proteins and is regulated at multiple levels. Several regulators of LPL activity have been known for years and have been investigated thoroughly, but several have been identified only recently, including an endothelial cell protein that transports LPL to the capillary lumen, a microRNA that reduces LPL transcript levels, a sorting protein that targets LPL for uptake and degradation, and a transcription factor that increases the expression of apolipoproteins that regulate LPL activity. Proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues. Recent studies have identified GPIHBP1 as the molecule that transports LPL to the capillary lumen, and have also identified other molecules that are potentially important for regulating LPL activity. These new discoveries open new doors for understanding basic mechanisms of lipolysis and hyperlipidemia.

LDL-Receptor Related Proteins - metabolism

Endothelial Cells - metabolism

Lipoprotein Lipase - genetics

Apolipoproteins - metabolism

Humans

MicroRNAs - metabolism

Lipid Mobilization

Brain - metabolism

Animals

Carrier Proteins - metabolism

Endothelium, Vascular - metabolism

Receptors, Lipoprotein

Membrane Transport Proteins - metabolism

Lipoprotein Lipase - metabolism

Details

Title: Subtitle: New wrinkles in lipoprotein lipase biology
Creators: Brandon S J Davies - Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. bdavies@mednet.ucla.edu
Anne P Beigneux
Loren G Fong
Stephen G Young
Resource Type: Journal article
Publication Details: Current opinion in lipidology, Vol.23(1), pp.35-42
DOI: 10.1097/MOL.0b013e32834d0b33
PMID: 22123668
PMCID: PMC3383841
NLM abbreviation: Curr Opin Lipidol
ISSN: 0957-9672
eISSN: 1473-6535
Publisher: England
Grant note: R01 HL094732 / NHLBI NIH HHS R01 HL087228 / NHLBI NIH HHS P01 HL090553 / NHLBI NIH HHS
Language: English
Date published: 02/2012
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
Record Identifier: 9984025250702771

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