Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus

Molly E McCarthy; Scott P Oltman; Rebecca J Baer; Kelli K Ryckman; Elizabeth E Rogers; Martina A Steurer-Muller; John S Witte; Laura L Jelliffe-Pawlowski

doi:10.1111/cts.12590

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Journal article

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Peer reviewed

Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus

Molly E McCarthy, Scott P Oltman, Rebecca J Baer, Kelli K Ryckman, Elizabeth E Rogers, Martina A Steurer-Muller, John S Witte and Laura L Jelliffe-Pawlowski

Clinical and translational science, Vol.12(1), pp.28-38

01/2019

DOI: 10.1111/cts.12590

PMCID: PMC6342241

PMID: 30369069

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Abstract

Our objective was to assess the relationship between hyperbilirubinemia with and without kernicterus and metabolic profile at newborn screening. Included were 1,693,658 infants divided into a training or testing subset in a ratio of 3:1. Forty-two metabolites were analyzed using logistic regression (odds ratios (ORs), area under the receiver operating characteristic curve (AUC), 95% confidence intervals (CIs)). Several metabolite patterns remained consistent across gestational age groups for hyperbilirubinemia without kernicterus. Thyroid stimulating hormone (TSH) and C-18:2 were decreased, whereas tyrosine and C-3 were increased in infants across groupings. Increased C-3 was also observed for kernicterus (OR: 3.17; 95% CI: 1.18-8.53). Thirty-one metabolites were associated with hyperbilirubinemia without kernicterus in the training set. Phenylalanine (OR: 1.91; 95% CI: 1.85-1.97), ornithine (OR: 0.76; 95% 0.74-0.77), and isoleucine + leucine (OR: 0.63; 95% CI: 0.61-0.65) were the most strongly associated. This study showed that newborn metabolic function is associated with hyperbilirubinemia with and without kernicterus.

Jaundice, Neonatal - diagnosis

Metabolomics

Bilirubin - metabolism

Ornithine - blood

Humans

Jaundice, Neonatal - metabolism

Male

Kernicterus - etiology

Infant, Premature - blood

Infant, Premature - metabolism

Female

Retrospective Studies

Infant, Newborn

Kernicterus - metabolism

Thyrotropin - blood

Biomarkers - metabolism

Isoleucine - blood

Leucine - metabolism

Phenylalanine - metabolism

Leucine - blood

Ornithine - metabolism

Metabolome

Neonatal Screening - methods

Biomarkers - blood

Kernicterus - blood

Thyrotropin - metabolism

Gestational Age

Kernicterus - diagnosis

Isoleucine - metabolism

Jaundice, Neonatal - blood

Bilirubin - blood

Phenylalanine - blood

Jaundice, Neonatal - complications

Details

Title: Subtitle: Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus
Creators: Molly E McCarthy - Department of Public Health, Brown University, Providence, Rhode Island, USA
Scott P Oltman - Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA
Rebecca J Baer - Department of Pediatrics, University of California San Diego, La Jolla, California, USA
Kelli K Ryckman - Departments of Epidemiology and Pediatrics, University of Iowa, Iowa City, Iowa, USA
Elizabeth E Rogers - Department of Pediatrics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA
Martina A Steurer-Muller - Department of Epidemiology and Biostatistics, Pediatrics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA
John S Witte - Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA
Laura L Jelliffe-Pawlowski - Department of Epidemiology and Biostatistics and the California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA
Resource Type: Journal article
Publication Details: Clinical and translational science, Vol.12(1), pp.28-38
DOI: 10.1111/cts.12590
PMID: 30369069
PMCID: PMC6342241
NLM abbreviation: Clin Transl Sci
ISSN: 1752-8062
eISSN: 1752-8062
Publisher: United States
Grant note: DOI: 10.13039/100000865, name: Bill and Melinda Gates Foundation, award: OPP1141549
Language: English
Date published: 01/2019
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983995004602771

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16 Times Cited - Web of Science