Journal article
Newly Postulated Neurodevelopmental Risks of Pediatric Anesthesia
Current neurology and neuroscience reports, Vol.11(2), pp.205-210
04/2011
DOI: 10.1007/s11910-010-0177-4
PMID: 21222179
Abstract
Recent animal and human studies have raised concern that exposure to anesthetic agents in children may cause neuronal damage and be associated with adverse neurodevelopmental outcomes. Exposure of young animals to anesthetic agents above threshold doses and durations during a critical neurodevelopmental window in the absence of concomitant painful stimuli causes widespread neuronal apoptosis and subsequent abnormal behaviors. The relevance of such animal data to humans is unknown. Untreated neonatal pain and stress also are associated with enhanced neuronal death and subsequent maladaptive behaviors, which can be prevented by exposure to these same anesthetic agents. Retrospective observational human studies have suggested a dose-dependent association between multiple anesthetic exposures in early childhood and subsequent learning disability, the causality of which is unknown. Ongoing prospective investigations are underway, the results of which may clarify if and what neurodevelopmental risks are associated with pediatric anesthesia. No change in current practice is yet indicated.
Details
- Title: Subtitle
- Newly Postulated Neurodevelopmental Risks of Pediatric Anesthesia
- Creators
- Stephen Hays - Division of Pediatric Anesthesia Monroe Carell Jr. Children’s Hospital at Vanderbilt 2200 Children’s Way # 3115 Nashville TN 37232-9070 USAJayant Deshpande - Department of Anesthesiology, Arkansas Children’s Hospital 1 Children’s Way Little Rock AR 72202-3591 USA
- Resource Type
- Journal article
- Publication Details
- Current neurology and neuroscience reports, Vol.11(2), pp.205-210
- Publisher
- Current Science Inc; New York
- DOI
- 10.1007/s11910-010-0177-4
- PMID
- 21222179
- ISSN
- 1528-4042
- eISSN
- 1534-6293
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Stead Family Department of Pediatrics; Anesthesia
- Record Identifier
- 9984006346302771
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