Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)

Sarah C Tinker; Suzan L Carmichael; Marlene Anderka; Marilyn L Browne; Kristin M Caspers Conway; Robert E Meyer; Wendy N Nembhard; Richard S Olney; Jennita Reefhuis; Birth Defects Study To Evaluate Pregnancy exposureS

doi:10.1002/bdra.23373

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Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)

Journal article

Peer reviewed

Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)

Sarah C Tinker, Suzan L Carmichael, Marlene Anderka, Marilyn L Browne, Kristin M Caspers Conway, Robert E Meyer, Wendy N Nembhard, Richard S Olney, Jennita Reefhuis and Birth Defects Study To Evaluate Pregnancy exposureS

Birth defects research. A Clinical and molecular teratology, Vol.103(8), pp.733-740

08/2015

DOI: 10.1002/bdra.23373

PMCID: PMC4537667

PMID: 25846741

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Abstract

The Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS) is a population-based, multi-Center case-control study of modifiable risk factors for selected birth defects in the United States. BD-STEPS is the second major research effort of the Centers for Birth Defects Research and Prevention, which extends and expands the initial research effort, the National Birth Defects Prevention Study (NBDPS). BD-STEPS focuses on 17 categories of structural birth defects selected based on severity, prevalence, consistent ascertainment, and previous findings that warrant additional research. Cases are identified through existing birth defects surveillance programs; controls are from vital records or birth hospital logs from the same catchment area. BD-STEPS uses a standardized computer-assisted telephone interview to collect information from case and control mothers on topics including demographics, health conditions, and medication use. Following the maternal interview, selected Centers request permission to sample residual newborn screening blood spots from state repositories for genetic analyses. New components planned for BD-STEPS include linkages with external datasets and use of online questionnaires to collect in-depth information on selected exposures. BD-STEPS extends NBDPS by continuing to collect data on many exposures that were assessed in NBDPS, allowing data from both studies to be combined and providing an unprecedented sample size to analyze rare exposures. BD-STEPS expands upon NBDPS by collecting more detailed information on existing exposures as well as new exposures. The goal of BD-STEPS is to provide women and healthcare providers with information they need to make decisions to promote the healthiest pregnancy possible.

Pregnancy

Registries

Biomedical Research

Case-Control Studies

Congenital Abnormalities - epidemiology

Congenital Abnormalities - etiology

Congenital Abnormalities - prevention & control

Female

Genetic Predisposition to Disease

Humans

Infant, Newborn

Maternal Exposure - adverse effects

Neonatal Screening

Population Surveillance

Research Design

Risk Factors

United States - epidemiology

Details

Title: Subtitle: Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS)
Creators: Sarah C Tinker - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia
Suzan L Carmichael - Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, California
Marlene Anderka - Center for Birth Defects Research and Prevention at the Massachusetts Department of Public Health, Boston, Massachusetts
Marilyn L Browne - Congenital Malformations Registry, New York State Department of Health, Albany, New York
Kristin M Caspers Conway - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa
Robert E Meyer - Birth Defects Monitoring Program, State Center for Health Statistics, North Carolina Division of Public Health, Raleigh, North Carolina
Wendy N Nembhard - Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas
Richard S Olney - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia
Jennita Reefhuis - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia
Birth Defects Study To Evaluate Pregnancy exposureS
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.103(8), pp.733-740
DOI: 10.1002/bdra.23373
PMID: 25846741
PMCID: PMC4537667
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley
Grant note: CC999999 / Intramural CDC HHS CDP 13-003 / HSRD VA U01 DD001035 / NCBDD CDC HHS
Language: English
Date published: 08/2015
Academic Unit: Epidemiology
Record Identifier: 9984214811002771

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