Journal article
Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration
The FASEB Journal, Vol.31(12), pp.5440-5452
12/2017
DOI: 10.1096/fj.201700221RR
PMID: 28842432
Abstract
ABSTRACT NAD+ depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD+ was shown to prevent neuronal degeneration in this process through mechanisms that remained to be determined. The activity of nicotinamide riboside (NR) in neuroprotective models and the recent description of extracellular conversion of NAD+ to NR prompted us to probe the effects of NAD+ and NR in protection against excitotoxicity. Here, we show that intracortical administration of NR but not NAD+ reduces brain damage induced by NMDA injection. Using cortical neurons, we found that provision of extracellular NR delays NMDA‐induced axonal degeneration (AxD) much more strongly than extracellular NAD+. Moreover, the stronger effect of NR compared to NAD+ depends of axonal stress since in AxD induced by pharmacological inhibition of nicotinamide salvage, both NAD+ and NR prevent neuronal death and AxD in a manner that depends on internalization of NR. Taken together, our findings demonstrate that NR is a better neuroprotective agent than NAD+ in excitotoxicity‐induced AxD and that axonal protection involves defending intracellular NAD+ homeostasis.—Vaur, P., Brugg, B., Mericskay, M., Li, Z., Schmidt, M. S., Vivien, D., Orset, C., Jacotot, E., Brenner, C., Duplus, E. Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration. FASEB J. 31, 5440–5452 (2017). www.fasebj.org
Details
- Title: Subtitle
- Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration
- Creators
- Pauline Vaur - Sorbonne UniversitésBernard Brugg - Sorbonne UniversitésMathias Mericskay - Université Paris SudZhenlin Li - Université Paris SudMark S Schmidt - University of IowaDenis Vivien - Université Caen NormandieCyrille Orset - Université Caen NormandieEtienne Jacotot - Sorbonne UniversitésCharles Brenner - University of IowaEric Duplus - Sorbonne Universités
- Resource Type
- Journal article
- Publication Details
- The FASEB Journal, Vol.31(12), pp.5440-5452
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fj.201700221RR
- PMID
- 28842432
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 13
- Grant note
- Agence Nationale pour la Recherche (ANR) (2011‐RPIB‐008‐001 2012‐17)
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788596002771
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