Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A J Trammell; Mark S Schmidt; Benjamin J Weidemann; Philip Redpath; Frank Jaksch; Ryan W Dellinger; Zhonggang Li; E Dale Abel; Marie E Migaud; Charles Brenner

doi:10.1038/ncomms12948

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Journal article

Open access

Peer reviewed

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Samuel A J Trammell, Mark S Schmidt, Benjamin J Weidemann, Philip Redpath, Frank Jaksch, Ryan W Dellinger, Zhonggang Li, E Dale Abel, Marie E Migaud and Charles Brenner

Nature communications, Vol.7(1), 12948

10/10/2016

DOI: 10.1038/ncomms12948

PMCID: PMC5062546

PMID: 27721479

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Abstract

Nicotinamide riboside (NR) is in wide use as an NAD precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD metabolism in humans. We report that human blood NAD can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual, and that oral NR elevates mouse hepatic NAD with distinct and superior pharmacokinetics to those of nicotinic acid and nicotinamide. We further show that single doses of 100, 300 and 1,000 mg of NR produce dose-dependent increases in the blood NAD metabolome in the first clinical trial of NR pharmacokinetics in humans. We also report that nicotinic acid adenine dinucleotide (NAAD), which was not thought to be en route for the conversion of NR to NAD , is formed from NR and discover that the rise in NAAD is a highly sensitive biomarker of effective NAD repletion.

Biomarkers - metabolism

Niacinamide - analogs & derivatives

Leukocytes, Mononuclear - metabolism

NAD - urine

NAD - analogs & derivatives

Niacinamide - metabolism

Administration, Oral

Humans

Liver - metabolism

Mice, Inbred C57BL

Middle Aged

Metabolome

Vitamins - metabolism

Biological Availability

Male

NAD - blood

Niacinamide - administration & dosage

Animals

Niacinamide - chemistry

Details

Title: Subtitle: Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Creators: Samuel A J Trammell - Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Mark S Schmidt - Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Benjamin J Weidemann - Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Philip Redpath - John King Laboratory, School of Pharmacy, Queens University Belfast, Belfast BT7 1NN, UK
Frank Jaksch - ChromaDex, Inc., 10005 Muirlands Blvd, Suite G, Irvine, California 92618, USA
Ryan W Dellinger - ChromaDex, Inc., 10005 Muirlands Blvd, Suite G, Irvine, California 92618, USA
Zhonggang Li - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
E Dale Abel - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Marie E Migaud - John King Laboratory, School of Pharmacy, Queens University Belfast, Belfast BT7 1NN, UK
Charles Brenner - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Resource Type: Journal article
Publication Details: Nature communications, Vol.7(1), 12948
DOI: 10.1038/ncomms12948
PMID: 27721479
PMCID: PMC5062546
NLM abbreviation: Nat Commun
ISSN: 2041-1723
eISSN: 2041-1723
Publisher: England
Grant note: R21 AA022371 / NIAAA NIH HHS R01 HL108379 / NHLBI NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 10/10/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9983788598902771

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