Journal article
Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition
Annual review of nutrition, Vol.28(1), pp.115-130
2008
DOI: 10.1146/annurev.nutr.28.061807.155443
PMID: 18429699
Abstract
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research.
Details
- Title: Subtitle
- Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition
- Creators
- Katrina L Bogan - Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. charles.brenner@dartmouth.eduCharles Brenner
- Resource Type
- Journal article
- Publication Details
- Annual review of nutrition, Vol.28(1), pp.115-130
- Publisher
- United States
- DOI
- 10.1146/annurev.nutr.28.061807.155443
- PMID
- 18429699
- ISSN
- 0199-9885
- eISSN
- 1545-4312
- Language
- English
- Date published
- 2008
- Academic Unit
- Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9983788433002771
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