Journal article
Nifedipine and the conditioning response
The American journal of cardiology, Vol.53(7), pp.908-911
03/15/1984
DOI: 10.1016/0002-9149(84)90523-X
PMID: 6702646
Abstract
The effect of nifedipine (N) on conditioning was studied in 14 healthy sedentary men, aged 20 to 34 years. Subjects were ranked according to maximal oxygen consumption (VO
2 max), paired, and 1 of each pair randomly assigned to take N, 20 mg, or placebo (C) 3 times daily. Exercise conditioning was 5 times/week for 6 weeks at >85% of maximal heart rate for both groups. Adherence to exercise was 81 % for the N and 82% for the C group. After training, the N group improved VO
2 max from 41.4 ± 1.4 to 51.6 ± 2.0
ml/
kg/
min (p <0.05) and exercise time from 22 ± 1 to 28 ± 1 minutes (p <0.05). Heart rate (HR) at rest and the product of heart rate and systolic blood pressure both decreased (p <0.05): 70 ± 6 to 55 ± 4
beats/
min; 9,300 ± 900 to 6,800 ± 700
beats/
min × mm Hg. In the C group, VO
2 max increased from 43.2 ± 2.5 to 49.9 ± 2.5
ml/
kg/
min (p <0.05); exercise duration improved from 24 ± 2 to 29 ± 2 minutes (p <0.05), and the rate-pressure product at rest decreased from 8,000 ± 400 to 6,700 ± 400 (p <0.05). Differences between N and C were not significant. Thus, N, unlike propranolol, does not inhibit the response to exercise conditioning.
Details
- Title: Subtitle
- Nifedipine and the conditioning response
- Creators
- Daniel J. Duffey - University of Colorado HealthLawrence D. Horwitz - University of Colorado HealthHomer L. Brammell - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.53(7), pp.908-911
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0002-9149(84)90523-X
- PMID
- 6702646
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 03/15/1984
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656598402771
Metrics
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