Journal article
Nine novel conserved motifs in BRCA1 identified by the chicken orthologue
Oncogene, Vol.20(32), pp.4433-4438
2001
DOI: 10.1038/sj.onc.1204485
PMID: 11466627
Abstract
The breast cancer susceptibility gene BRCA1 encodes a multifunctional protein that is mutated in many hereditary breast and ovarian cancers. We have cloned a homologue of the human BRCA1 gene from chicken; the gene encodes a 1749 amino acid protein that is 33% identical to human BRCA1. Phylogenetic analyses of the chicken and mammalian proteins indicate that the chicken gene is a bona fide BRCA1 orthologue, the first to be described from a non-mammal. Most of the chicken protein has diverged considerably from its mammalian orthologues, although the RING and BRCT repeat regions are highly conserved. This marked overall sequence divergence has allowed us to identify nine additional highly-conserved motifs (ranging from 8-56 amino acids in length) which are likely important for BRCA1 function.
Details
- Title: Subtitle
- Nine novel conserved motifs in BRCA1 identified by the chicken orthologue
- Creators
- Brian J Orelli - Department of Radiation and Cellular Oncology, University of Chicago, 920 E 58th Street, Chicago, Illinois, IL 60637, United StatesJohn M Logsdon - Department of Biology, Emory University, 1510 Clifton Road., Atlanta, Georgia, GA 30322, United StatesDouglas K Bishop - Department of Radiation and Cellular Oncology, University of Chicago, 920 E 58th Street, Chicago, Illinois, IL 60637, United States
- Resource Type
- Journal article
- Publication Details
- Oncogene, Vol.20(32), pp.4433-4438
- DOI
- 10.1038/sj.onc.1204485
- PMID
- 11466627
- NLM abbreviation
- Oncogene
- ISSN
- 0950-9232
- eISSN
- 1476-5594
- Publisher
- Nature Publishing
- Language
- English
- Date published
- 2001
- Academic Unit
- Biology
- Record Identifier
- 9984217527202771
Metrics
10 Record Views