Journal article
Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus
The European journal of neuroscience, Vol.52(9), pp.4057-4080
11/2020
DOI: 10.1111/ejn.14913
PMID: 32686192
Abstract
Previous work has led to the hypothesis that, during the production of noise-induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypothesis, we noise-exposed 26 guinea pigs, identified evidence of tinnitus in 12 of them and then compared the effects of an iontophoretically applied NO donor or production inhibitor on VCN single unit activity. We confirmed that the mean driven firing rate for the tinnitus and control groups was the same while it had fallen in the non-tinnitus group. By contrast, the mean spontaneous rate had increased for the tinnitus group relative to the control group, while it remained the same for the non-tinnitus group. A greater proportion of units responded to exogenously applied NO in the tinnitus (56%) and non-tinnitus groups (71%) than a control population (24%). In the tinnitus group, endogenous NO facilitated the driven firing rate in 37% (7/19) of neurons and appeared to bring the mean driven rate back up to control levels by a mechanism involving N-methyl-D-aspartic acid (NMDA) receptors. By contrast, in the non-tinnitus group, endogenous NO only facilitated the driven firing rate in 5% (1/22) of neurons and there was no facilitation of driven rate in the control group. The effects of endogenous NO on spontaneous activity were unclear. These results suggest that NO is involved in increasing the gain applied to driven activity, but other factors are also involved in the increase in spontaneous activity.
Details
- Title: Subtitle
- Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus
- Creators
- Adam Hockley - MRC Institute of Hearing ResearchJoel I Berger - MRC Institute of Hearing ResearchAlan R Palmer - MRC Institute of Hearing ResearchMark N Wallace - University of Nottingham
- Resource Type
- Journal article
- Publication Details
- The European journal of neuroscience, Vol.52(9), pp.4057-4080
- DOI
- 10.1111/ejn.14913
- PMID
- 32686192
- NLM abbreviation
- Eur J Neurosci
- ISSN
- 0953-816X
- eISSN
- 1460-9568
- Grant note
- RS_1595452 / Medical Research Council TRIH 2018 / RNID MC_U135097126 / Medical Research Council MC_UU_00010/5 / Medical Research Council T8 / RNID
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984618522302771
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