Journal article
Nitroxidergic innervation of human cerebral arteries
Autonomic neuroscience, Vol.156(1), pp.152-153
2010
DOI: 10.1016/j.autneu.2010.04.012
PMCID: PMC2914153
PMID: 20537599
Abstract
A dense network of nerves containing neuronal nitric oxide synthase is present in cerebral vessels from experimental animals. The nerves may regulate cerebrovascular tone, protect the brain from stroke, and contribute to cluster headaches in humans; but studies in humans have shown only modest nitroxidergic innervation of cerebral vessels. We tested the hypothesis that nerve fibers containing neuronal nitric oxide synthase richly innervate human cerebral arteries. We used immunohistochemical techniques at post mortem and found dense neuronal nitric oxide synthase nerve staining in human cerebral vessel walls consistent with participation of nitroxidergic fibers in human physiological and pathophysiological processes.
Details
- Title: Subtitle
- Nitroxidergic innervation of human cerebral arteries
- Creators
- Otar M Taktakishvili - Department of Neurology, Univ. of Iowa, Iowa City, IA 52242, United StatesLi-Hsien Lin - Department of Neurology, Univ. of Iowa, Iowa City, IA 52242, United StatesAndrew D Vanderheyden - Department of Pathology, Univ. of Iowa, Iowa City, IA 52242, United StatesMarcus B Nashelsky - Department of Pathology, Univ. of Iowa, Iowa City, IA 52242, United StatesWilliam T Talman - Department of Neurology, Univ. of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Autonomic neuroscience, Vol.156(1), pp.152-153
- DOI
- 10.1016/j.autneu.2010.04.012
- PMID
- 20537599
- PMCID
- PMC2914153
- NLM abbreviation
- Auton Neurosci
- ISSN
- 1566-0702
- eISSN
- 1872-7484
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2010
- Academic Unit
- Neurology; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984047636102771
Metrics
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