Journal article
Nk6, a novel Drosophila homeobox gene regulated by vnd
Mechanisms of development, Vol.116(1), pp.105-116
2002
DOI: 10.1016/S0925-4773(02)00155-7
PMID: 12128210
Abstract
Nk(
x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel
Drosophila gene,
Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins are highly conserved.
Nk6 is expressed in the embryonic brain, ventral nerve cord, hindgut, and internal head structures. Nerve cord expression is in midline precursors, several ventral and intermediate column neuroblasts, and later in neurons but not glia, similar to the known expression of
Nkx6 genes in the neural tube. We show genetically that
Nk6 is positively regulated, directly or indirectly, by
vnd in brain precursors. In
vnd mutants, head neuroectoderm
Nk6 expression is abolished where it is normally co-expressed with
vnd. Conversely,
vnd-overexpression leads to ectopic
Nk6 expression in the brain. These findings further highlight the importance of interactions between
Nk(
x)-type genes in regulating their expression.
Details
- Title: Subtitle
- Nk6, a novel Drosophila homeobox gene regulated by vnd
- Creators
- Jay Uhler - Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USAJames Garbern - Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USALi Yang - Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USAJohn Kamholz - Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USADervla M Mellerick - Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
- Resource Type
- Journal article
- Publication Details
- Mechanisms of development, Vol.116(1), pp.105-116
- DOI
- 10.1016/S0925-4773(02)00155-7
- PMID
- 12128210
- NLM abbreviation
- Mech Dev
- ISSN
- 0925-4773
- eISSN
- 1872-6356
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 2002
- Academic Unit
- Neurology; Psychiatry
- Record Identifier
- 9984020633502771
Metrics
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