Journal article
Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
The Journal of immunology (1950), Vol.200(3), pp.1188-1197
02/01/2018
DOI: 10.4049/jimmunol.1700999
PMCID: PMC5831365
PMID: 29282312
Abstract
Exaggerated inflammatory responses during influenza A virus (IAV) infection are typically associated with severe disease. Neutrophils are among the immune cells that can drive this excessive and detrimental inflammation. In moderation, however, neutrophils are necessary for optimal viral control. In this study, we explore the role of the nucleotide-binding domain leucine-rich repeat containing receptor family member Nlrp12 in modulating neutrophilic responses during lethal IAV infection.
mice are protected from lethality during IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and a reduction in levels of neutrophil chemoattractant CXCL1 in their lungs compared with wild-type mice.
neutrophils and dendritic cells within the IAV-infected lungs produce less CXCL1 than their wild-type counterparts. Decreased CXCL1 production by
dendritic cells was not due to a difference in CXCL1 protein stability, but instead to a decrease in
mRNA stability. Together, these data demonstrate a previously unappreciated role for Nlrp12 in exacerbating the pathogenesis of IAV infection through the regulation of CXCL1-mediated neutrophilic responses.
Details
- Title: Subtitle
- Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
- Creators
- Emma E Hornick - Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Balaji Banoth - Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048Ann M Miller - Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Zeb R Zacharias - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Nidhi Jain - Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048Mary E Wilson - Veterans Affairs Medical Center, Iowa City, IA 52246; andKatherine N Gibson-Corley - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Kevin L Legge - Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Gail A Bishop - Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242Fayyaz S Sutterwala - Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048Suzanne L Cassel - Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.200(3), pp.1188-1197
- DOI
- 10.4049/jimmunol.1700999
- PMID
- 29282312
- PMCID
- PMC5831365
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- P30 ES005605 / NIEHS NIH HHS T32 CA078586 / NCI NIH HHS R01 AI118719 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS I01 BX001983 / BLRD VA R01 AI104706 / NIAID NIH HHS P30 DK054759 / NIDDK NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 02/01/2018
- Academic Unit
- Microbiology and Immunology; President; International Programs; Epidemiology; Pathology; Radiation Research Laboratory; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984002397002771
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