No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation

Rebecca M Kappus; Kanokwan Bunsawat; Alexander J Rosenberg; Bo Fernhall

doi:10.1055/s-0042-119203

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No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation

Journal article

Peer reviewed

No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation

Rebecca M Kappus, Kanokwan Bunsawat, Alexander J Rosenberg and Bo Fernhall

International journal of sports medicine, Vol.38(3), pp.193-200

03/01/2017

DOI: 10.1055/s-0042-119203

PMCID: PMC7996076

PMID: 28219102

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https://www.ncbi.nlm.nih.gov/pmc/articles/7996076View

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Abstract

This study investigated the effects of acute antioxidant supplementation on endothelial function, exercise blood flow and oxidative stress biomarkers in 9 young African American compared to 10 Caucasian males (25.7±1.2 years). We hypothesized that African American males would have lower exercise blood flow and endothelial responsiveness compared to Caucasian males, and these responses would be improved following antioxidant supplementation. Ultrasonography was used to measure blood flow during handgrip exercise. Endothelial function was assessed using flow-mediated dilation, and lipid peroxidation was assessed by measuring levels of malondialdehyde-thiobarbituric acid reactive substances. African American males exhibited lower endothelial function than Caucasians at baseline (8.3±1.7 vs. 12.2±1.7%) and the difference was ameliorated with antioxidant supplementation (10.7±1.9% vs. 10.8±1.8%), but the interaction was not significant (p=0.10). There were no significant changes in malondialdehyde-thiobarbituric acid reactive substances following antioxidant supplementation. There was a significant increase in brachial blood flow and forearm vascular conductance with exercise but no differences with antioxidant supplementation. There were no group differences in exercise responses and no differences with antioxidant supplementation, suggesting a lack of influence of oxidative stress during exercise in this cohort.

Adult

African Americans

Antioxidants - pharmacology

Biomarkers - blood

Cross-Over Studies

Dietary Supplements

Double-Blind Method

Endothelium, Vascular - physiology

European Continental Ancestry Group

Exercise - physiology

Forearm - blood supply

Hand Strength

Humans

Lipid Peroxidation

Male

Malondialdehyde - blood

Oxidative Stress

Regional Blood Flow

Thiobarbituric Acid Reactive Substances - analysis

Young Adult

Details

Title: Subtitle: No Evidence of Racial Differences in Endothelial Function and Exercise Blood Flow in Young, Healthy Males Following Acute Antioxidant Supplementation
Creators: Rebecca M Kappus - Appalachian State University
Kanokwan Bunsawat - University of Illinois Urbana-Champaign
Alexander J Rosenberg - University of Illinois Urbana-Champaign
Bo Fernhall - University of Illinois Urbana-Champaign
Resource Type: Journal article
Publication Details: International journal of sports medicine, Vol.38(3), pp.193-200
DOI: 10.1055/s-0042-119203
PMID: 28219102
PMCID: PMC7996076
NLM abbreviation: Int J Sports Med
ISSN: 0172-4622
eISSN: 1439-3964
Grant note: UL1 TR000050 / NCATS NIH HHS
Language: English
Date published: 03/01/2017
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948043502771

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