Journal article
No Evidence of a Schizophrenia Locus in a Second Pseudoautosomal Region
Archives of general psychiatry, Vol.51(5), pp.427-427
05/01/1994
DOI: 10.1001/archpsyc.1994.03950050087010
PMID: 8179466
Abstract
W have previously reported that we found no evidence of linkage between schizophrenia and the pseudoautosomal region of the X and Y chromosomes in our series of pedigrees.1 The pseudoautosomal region we tested is located at the telomere of the short arms. Recently, a second pseudoautosomal region has been found at the telomere of the long arms as well.2 This latter region spans over 400 kilobases in physical distance and approximately 2 centimorgans in map distance. A highly polymorphic marker, sDF-1 (DXYS154), has been identified in this region.To search for a schizophrenia vulnerability locus in the second pseudoautosomal region, we tested for linkage to the above marker in our 12 pedigrees.1 The polymerase chain reaction conditions are essentially as those described previously.2 The models used in the linkage analyses were also the same as those previously reported,1 except that the male-to-female recombination ratio was
Details
- Title: Subtitle
- No Evidence of a Schizophrenia Locus in a Second Pseudoautosomal Region
- Creators
- Zhe Wu WangDonald W BlackNancy AndreasenRaymond R Crowe
- Resource Type
- Journal article
- Publication Details
- Archives of general psychiatry, Vol.51(5), pp.427-427
- DOI
- 10.1001/archpsyc.1994.03950050087010
- PMID
- 8179466
- NLM abbreviation
- Arch Gen Psychiatry
- ISSN
- 0003-990X
- eISSN
- 1538-3636
- Publisher
- American Medical Association
- Language
- English
- Date published
- 05/01/1994
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003467402771
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