No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Bharat Thyagarajan; Kristin E Anderson; Aaron R Folsom; David R Jacobs; Charles F Lynch; Archana Bargaje; Waseem Khaliq; Myron D Gross

doi:10.1016/j.cdp.2006.07.002

Journal article

No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study

Bharat Thyagarajan, Kristin E Anderson, Aaron R Folsom, David R Jacobs, Charles F Lynch, Archana Bargaje, Waseem Khaliq and Myron D Gross

Cancer detection and prevention, Vol.30(4), pp.313-321

2006

DOI: 10.1016/j.cdp.2006.07.002

PMID: 16963196

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Abstract

Background: Genetic variation in DNA repair may contribute to differences in the susceptibility of several cancers. We evaluated two polymorphisms in the base excision repair pathway (BER) (XRCC1; Arg194Trp and Arg399Gln) and one polymorphism in the double strand DNA repair pathway (XRCC3; Thr241Met) for their association with breast cancer risk. Methods: The association was analyzed in a nested case control study of 460 breast cancer cases and 324 cancer-free controls within the Iowa Women's Health Cohort. DNA was obtained from blood samples or paraffin embedded tissues (PET) and all samples were genotyped by one of three genotyping platforms—PCR-RFLP, PCR-INVADER, or Sequenom. Results: None of the three polymorphisms studied were significantly associated with breast cancer risk (XRCC1: Arg194Trp (OR = 1.21, 95% CI: 0.78–1.88); Arg399Gln (OR = 1.20, 95% CI: 0.80–1.79); XRCC3: Thr241Met (OR = 1.04, 95% CI: 0.76–1.41). Conclusions: These results suggest that independently these polymorphisms of XRCC1 and XRCC3 genes do not contribute significantly to the genetic susceptibility of breast cancer.

Arg399Gln

Statistical analysis

INVADER assay

Postmenopausal breast cancer

Paraffin embedded tissue

Genotype

Polymorphisms

DNA repair

Base excision repair

Risk factors

Nested case control study

IWHS

Double strand DNA repair

BMI

Details

Title: Subtitle: No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study
Creators: Bharat Thyagarajan - University of Minnesota, Division of Epidemiology, Suite 300, West Bank Office Building, Minneapolis, MN 55454, United States
Kristin E Anderson - University of Minnesota, Division of Epidemiology, Suite 300, West Bank Office Building, Minneapolis, MN 55454, United States
Aaron R Folsom - University of Minnesota, Division of Epidemiology, Suite 300, West Bank Office Building, Minneapolis, MN 55454, United States
David R Jacobs - University of Minnesota, Division of Epidemiology, Suite 300, West Bank Office Building, Minneapolis, MN 55454, United States
Charles F Lynch - University of Iowa, Department of Epidemiology, Iowa City, IA 52242, United States
Archana Bargaje - Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street S. E., Minneapolis, MN 55455, United States
Waseem Khaliq - University of Minnesota, Division of Epidemiology, Suite 300, West Bank Office Building, Minneapolis, MN 55454, United States
Myron D Gross - Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street S. E., Minneapolis, MN 55455, United States
Resource Type: Journal article
Publication Details: Cancer detection and prevention, Vol.30(4), pp.313-321
DOI: 10.1016/j.cdp.2006.07.002
PMID: 16963196
NLM abbreviation: Cancer Detect Prev
ISSN: 0361-090X
eISSN: 1873-443X
Publisher: Elsevier Ltd
Language: English
Date published: 2006
Academic Unit: Epidemiology
Record Identifier: 9983995109402771

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