Journal article
No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia
Psychiatric genetics, Vol.16(5), pp.221-223
10/2006
DOI: 10.1097/01.ypg.0000242192.28526.fa
PMID: 16969279
Abstract
Some serological and genetic studies have suggested that alterations in folate metabolism are associated with increased vulnerability to schizophrenia. In particular, these findings are most striking for the role of a putatively functional variant (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene. To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample. Neither the T allele nor the TT genotype was associated with increased risk for schizophrenia. These results do not support a role for the C677T MTHFR variant in schizophrenia.
Details
- Title: Subtitle
- No association of the C677T methylenetetrahydrofolate reductase polymorphism with schizophrenia
- Creators
- Robert Philibert - Department of Psychiatry, The University of Iowa, Psychiatry Research/MEB, Iowa City, IA 52242-1000, USA. robert-philibert@uiowa.eduTracy GunterNancy HollenbeckWilliam J AdamsPhillip BohleHans PackerHarinder Sandhu
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.16(5), pp.221-223
- DOI
- 10.1097/01.ypg.0000242192.28526.fa
- PMID
- 16969279
- NLM abbreviation
- Psychiatr Genet
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Publisher
- England
- Grant note
- DA015789 / NIDA NIH HHS K08MH064714 / NIMH NIH HHS
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003959902771
Metrics
18 Record Views