No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population

Isabelle Schrauwen; Melissa Thys; Kathleen Vanderstraeten; Erik Fransen; Megan Ealy; Cor W R J Cremers; Ingeborg Dhooge; Paul Van de Heyning; Erwin Offeciers; Richard J H Smith; Guy Van Camp

doi:10.1097/MAO.0b013e3181ab3058

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No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population

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No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population

Isabelle Schrauwen, Melissa Thys, Kathleen Vanderstraeten, Erik Fransen, Megan Ealy, Cor W R J Cremers, Ingeborg Dhooge, Paul Van de Heyning, Erwin Offeciers, Richard J H Smith, …

Otology & neurotology, Vol.30(8), pp.1079-1083

12/2009

DOI: 10.1097/MAO.0b013e3181ab3058

PMID: 19503013

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Abstract

Otosclerosis is a frequent cause of hearing impairment in the Caucasian population and is characterized by abnormal bone remodeling of the otic capsule. Associations with several genes have been reported, and recently, an association between the renin-angiotensin-aldosterone system and otosclerosis has been suggested. Polymorphisms in 3 genes were investigated: angiotensinogen (AGT), angiotensin I-converting enzyme (ACE), and angiotensin II receptor, type 1. The polymorphisms in AGT and ACE were associated with disease, and both were reported to interact with each other. In the current study, a replication study was done in a large Belgian-Dutch population to investigate whether this association could be replicated. The same 3 polymorphisms in AGT, ACE, and angiotensin II receptor, type 1 as analyzed in the original study were investigated in 692 otosclerosis patients and 692 controls of Belgian-Dutch origin. None of the polymorphisms were significantly associated with disease. Interaction between AGT and ACE polymorphisms was not significant either. We could not confirm the association between AGT and ACE, nor could we find evidence for interaction between both genes in otosclerosis. Because the current patient set is much larger than the one from the original study, this study holds sufficient power to detect the previously reported associations. Nonreplication in this case probably indicates that the initial results were false positive, although a role for these genes in otosclerosis cannot be definitively ruled out.

Data Interpretation, Statistical

Belgium - epidemiology

Netherlands - epidemiology

Genotype

Renin-Angiotensin System - genetics

Otosclerosis - epidemiology

Reverse Transcriptase Polymerase Chain Reaction

Polymorphism, Genetic

DNA - genetics

Angiotensinogen - genetics

Peptidyl-Dipeptidase A - genetics

Receptor, Angiotensin, Type 1 - genetics

Otosclerosis - genetics

Details

Title: Subtitle: No evidence for association between the renin-angiotensin-aldosterone system and otosclerosis in a large Belgian-Dutch population
Creators: Isabelle Schrauwen - Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Melissa Thys
Kathleen Vanderstraeten
Erik Fransen
Megan Ealy
Cor W R J Cremers
Ingeborg Dhooge
Paul Van de Heyning
Erwin Offeciers
Richard J H Smith
Guy Van Camp
Resource Type: Journal article
Publication Details: Otology & neurotology, Vol.30(8), pp.1079-1083
DOI: 10.1097/MAO.0b013e3181ab3058
PMID: 19503013
NLM abbreviation: Otol Neurotol
ISSN: 1531-7129
eISSN: 1537-4505
Publisher: United States
Language: English
Date published: 12/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
Record Identifier: 9984006309502771

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