No observed association for mitochondrial SNPs with preterm delivery and related outcomes

Brandon W Alleman; Solveig Myking; Kelli K Ryckman; Ronny Myhre; Eleanor Feingold; Bjarke Feenstra; Frank Geller; Heather A Boyd; John R Shaffer; Qi Zhang; Ferdouse Begum; David Crosslin; Kim Doheny; Elizabeth Pugh; Aase Serine Devold Pay; Ingrid H G Ostensen; Nils-Halvdan Morken; Per Magnus; Mary L Marazita; Bo Jacobsson; Mads Melbye; Jeffrey C Murray; Norwegian Mother and Child Cohort Study (MoBA) Genome-Wide Association Study Group

doi:10.1038/pr.2012.112

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No observed association for mitochondrial SNPs with preterm delivery and related outcomes

Journal article

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Peer reviewed

No observed association for mitochondrial SNPs with preterm delivery and related outcomes

Brandon W Alleman, Solveig Myking, Kelli K Ryckman, Ronny Myhre, Eleanor Feingold, Bjarke Feenstra, Frank Geller, Heather A Boyd, John R Shaffer, Qi Zhang, …

Pediatric research, Vol.72(5), pp.539-544

11/2012

DOI: 10.1038/pr.2012.112

PMCID: PMC3694399

PMID: 22902432

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Abstract

Preterm delivery (PTD) is the leading cause of neonatal morbidity and mortality. Epidemiologic studies indicate recurrence of PTD is maternally inherited, creating a strong possibility that mitochondrial variants contribute to its etiology. This study examines the association between mitochondrial genotypes and PTD and related outcomes. This study combined, through meta-analysis, two case-control, genome-wide association studies: one from the Danish National Birth Cohort Study and one from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. The outcomes of PTD (≤36 wk), very PTD (≤32 wk), and preterm prelabor rupture of membranes (PPROM) were examined. A total of 135 individual single-nucleotide polymorphism (SNP) associations were tested using the combined genome from mothers and neonates (case vs. control) in each population and then pooled via meta-analysis. After meta-analysis, there were four SNPs for the outcome of PTD below P ≤ 0.10 and two below P ≤ 0.05. For the additional outcomes of very PTD and PPROM, there were three and four SNPs, respectively, below P ≤ 0.10. Given the number of tests, no single SNP reached study-wide significance (P = 0.0006). Our study does not support the hypothesis that mitochondrial genetics contributes to the maternal transmission of PTD and related outcomes.

Denmark

Norway

Phenotype

Genetic Predisposition to Disease

Genome-Wide Association Study

Premature Birth - genetics

Risk Assessment

Humans

Risk Factors

Chi-Square Distribution

Gestational Age

Case-Control Studies

DNA, Mitochondrial - genetics

Infant, Premature

Polymorphism, Single Nucleotide

Odds Ratio

Infant, Newborn

Details

Title: Subtitle: No observed association for mitochondrial SNPs with preterm delivery and related outcomes
Creators: Brandon W Alleman - Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
Solveig Myking
Kelli K Ryckman
Ronny Myhre
Eleanor Feingold
Bjarke Feenstra
Frank Geller
Heather A Boyd
John R Shaffer
Qi Zhang - University of Washington
Ferdouse Begum
David Crosslin
Kim Doheny
Elizabeth Pugh
Aase Serine Devold Pay
Ingrid H G Ostensen
Nils-Halvdan Morken
Per Magnus - Norwegian Institute of Public Health
Mary L Marazita
Bo Jacobsson
Mads Melbye
Jeffrey C Murray
Norwegian Mother and Child Cohort Study (MoBA) Genome-Wide Association Study Group
Resource Type: Journal article
Publication Details: Pediatric research, Vol.72(5), pp.539-544
DOI: 10.1038/pr.2012.112
PMID: 22902432
PMCID: PMC3694399
NLM abbreviation: Pediatr Res
ISSN: 1530-0447
eISSN: 1530-0447
Publisher: United States
Grant note: HHSN268200782096 / PHS HHS 1 U01 NS 047537-01 / NINDS NIH HHS T32 GM007337 / NIGMS NIH HHS HD52953 / NICHD NIH HHS U01HG004438 / NHGRI NIH HHS R01 HD057192 / NICHD NIH HHS U01 HG004446 / NHGRI NIH HHS U01 HG004438 / NHGRI NIH HHS U01 HG004423 / NHGRI NIH HHS U01HG04424 / NHGRI NIH HHS HD57192 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS U01 HG004424 / NHGRI NIH HHS U01 NS047537 / NINDS NIH HHS N01ES75558 / NIEHS NIH HHS HHSN268200782096C / NHLBI NIH HHS N0-ES-75558 / NIEHS NIH HHS
Language: English
Date published: 11/2012
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
Record Identifier: 9983995002902771

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