Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Carolina Pinzon-Guzman; Sreedhara Sangadala; Katherine M. Riera; Evgenya Y. Popova; Elizabeth Manning; Won Jae Huh; Matthew S. Alexander; Julia S. Shelton; Scott D. Boden; James R. Goldenring

doi:10.1172/JCI123597

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Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Journal article

Open access

Peer reviewed

Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia

Carolina Pinzon-Guzman, Sreedhara Sangadala, Katherine M. Riera, Evgenya Y. Popova, Elizabeth Manning, Won Jae Huh, Matthew S. Alexander, Julia S. Shelton, Scott D. Boden and James R. Goldenring

The Journal of clinical investigation, Vol.130(8), pp.4396-4410

07/20/2020

DOI: 10.1172/JCI123597

PMCID: PMC7410075

PMID: 32427591

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https://doi.org/10.1172/JCI123597View

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Abstract

Esophageal atresia (EA/TEF) is a common congenital abnormality present in 1 of 4000 births. Here we show that atretic esophagi lack Noggin (NOG) expression, resulting in immature esophagus that contains respiratory glands. Moreover, when using mouse esophageal organoid units (EOUs) or tracheal organoid units (TOUs) as a model of foregut development and differentiation in vitro, NOG determines whether foregut progenitors differentiate toward esophageal or tracheal epithelium. These results indicate that NOG is a critical regulator of cell fate decisions between esophageal and pulmonary morphogenesis, and its lack of expression results in EA/TEF.

Development

Embryonic development

Human stem cells

Surgery

Details

Title: Subtitle: Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia
Creators: Carolina Pinzon-Guzman - Vanderbilt University Medical Center
Sreedhara Sangadala - Emory University
Katherine M. Riera - Vanderbilt University Medical Center
Evgenya Y. Popova - Pennsylvania State University
Elizabeth Manning - Vanderbilt University Medical Center
Won Jae Huh - Vanderbilt University Medical Center
Matthew S. Alexander - University of Iowa Hospitals and Clinics
Julia S. Shelton - University of Iowa Stead Family Children’s Hospital
Scott D. Boden - Emory University
James R. Goldenring - Vanderbilt University Medical Center
Resource Type: Journal article
Publication Details: The Journal of clinical investigation, Vol.130(8), pp.4396-4410
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI123597
PMID: 32427591
PMCID: PMC7410075
ISSN: 0021-9738
eISSN: 1558-8238
Grant note: Award (I01 BX000930) / Department of Veterans Affairs Merit Review CA160479 / DOD RO1 DK071590 / NIH VICTR (VR15139.1) / Vanderbilt Emory Orthopaedics Seed Grant / Emory NA / The Helen and Nicholas Abumrad Research Fund Vanderbilt Digestive Disease Center,(P30 DK058404) / Vanderbilt T32 CA106183 / NIH R21TR001751 / NIH
Language: English
Date published: 07/20/2020
Academic Unit: Stead Family Department of Pediatrics; Surgery
Record Identifier: 9984322803002771

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