Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

Tang-Chuan Wang; Ta-Yuan Chang; Richard Tyler; Ying-Ju Lin; Wen-Miin Liang; Yio-Wha Shau; Wei-Yong Lin; Yi-Wen Chen; Chia-Der Lin; Ming-Hsui Tsai

doi:10.3390/brainsci10100732

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Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

Journal article

Open access

Peer reviewed

Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

Tang-Chuan Wang, Ta-Yuan Chang, Richard Tyler, Ying-Ju Lin, Wen-Miin Liang, Yio-Wha Shau, Wei-Yong Lin, Yi-Wen Chen, Chia-Der Lin and Ming-Hsui Tsai

Brain sciences, Vol.10(10), p.1

10/01/2020

DOI: 10.3390/brainsci10100732

PMID: 33066210

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Abstract

Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.

hidden hearing loss

central auditory system

maladaptive plasticity

neural plasticity

tinnitus

Review

cochlear damage

deafferentation

noise induced hearing loss

Details

Title: Subtitle: Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention
Creators: Tang-Chuan Wang - Department of Public Health, China Medical University, Taichung City 40402, Taiwan
Ta-Yuan Chang - Department of Occupational Safety and Health, China Medical University, Taichung City 40402, Taiwan
Richard Tyler - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA 52242-1396, USA
Ying-Ju Lin - School of Chinese Medicine, China Medical University, Taichung City 40402, Taiwan
Wen-Miin Liang - Department of Health Services Administration, China Medical University, Taichung City 40402, Taiwan
Yio-Wha Shau - College of Biomedical Engineering, China Medical University, Taichung City 40402, Taiwan
Wei-Yong Lin - Graduate Institute of Integrated Medicine, China Medical University, Taichung City 40402, Taiwan
Yi-Wen Chen - Graduate Institute of Biomedical Sciences, China Medical University, Taichung City 40402, Taiwan
Chia-Der Lin - School of Medicine, China Medical University, Taichung City 40402, Taiwan
Ming-Hsui Tsai - School of Medicine, China Medical University, Taichung City 40402, Taiwan
Resource Type: Journal article
Publication Details: Brain sciences, Vol.10(10), p.1
DOI: 10.3390/brainsci10100732
PMID: 33066210
NLM abbreviation: Brain Sci
ISSN: 2076-3425
eISSN: 2076-3425
Publisher: MDPI
Language: English
Date published: 10/01/2020
Academic Unit: Communication Sciences and Disorders; Otolaryngology; University College Courses
Record Identifier: 9984066332002771

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