Non-Conventional Treatments for Conventional Chondrosarcoma

Varun Monga; Hariharasudan Mani; Angela Hirbe; Mohammed Milhem

doi:10.3390/cancers12071962

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Non-Conventional Treatments for Conventional Chondrosarcoma

Journal article

Open access

Peer reviewed

Non-Conventional Treatments for Conventional Chondrosarcoma

Varun Monga, Hariharasudan Mani, Angela Hirbe and Mohammed Milhem

Cancers, Vol.12(7), pp.1-12

07/01/2020

DOI: 10.3390/cancers12071962

PMCID: PMC7409290

PMID: 32707689

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Abstract

Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma.

Life Sciences & Biomedicine

Oncology

Science & Technology

Details

Title: Subtitle: Non-Conventional Treatments for Conventional Chondrosarcoma
Creators: Varun Monga - University of Iowa
Hariharasudan Mani - University of Iowa
Angela Hirbe - Washington University in St. Louis
Mohammed Milhem - University of Iowa
Resource Type: Journal article
Publication Details: Cancers, Vol.12(7), pp.1-12
DOI: 10.3390/cancers12071962
PMID: 32707689
PMCID: PMC7409290
NLM abbreviation: Cancers (Basel)
ISSN: 2072-6694
eISSN: 2072-6694
Publisher: Mdpi
Number of pages: 12
Grant note: Rising Tide Foundation for Clinical Cancer Research 3P30CA086862-14S1 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
Language: English
Date published: 07/01/2020
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359885402771

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