Journal article
Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood
Pediatrics (Evanston), Vol.145(4), pp.1-9
04/2020
DOI: 10.1542/peds.2019-2114
PMCID: PMC7111486
PMID: 32209701
Abstract
Elevated non-high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non-HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non-HDL-C status predicts high common carotid artery intima-media thickness in adulthood.
We analyzed data from 4 prospective cohorts among 4582 children aged 3 to 19 years who were remeasured as adults (mean follow-up of 26 years). Non-HDL-C status in youth and adulthood was classified according to cut points of the National Heart, Lung, and Blood Institute and the National Cholesterol Education Program Adult Treatment Panel III. High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness.
In a log-binomial regression analysis adjusted with age at baseline, sex, cohort, length of follow-up, baseline BMI, and systolic blood pressure, children with dyslipidemic non-HDL-C were at increased risk of high cIMT in adulthood (relative risk [RR], 1.29; 95% confidence interval [CI], 1.07-1.55). Compared with the persistent normal group, the persistent dyslipidemia group (RR, 1.80; 95% CI, 1.37-2.37) and incident dyslipidemia (normal to dyslipidemia) groups (RR, 1.45; 95% CI, 1.07-1.96) had increased risk of high cIMT in adulthood, but the risk was attenuated for the resolution (dyslipidemia to normal) group (RR, 1.17; 95% CI, 0.97-1.41).
Dyslipidemic non-HDL-C levels predict youth at risk for developing high cIMT in adulthood. Those who resolve their non-HDL-C dyslipidemia by adulthood have normalized risk of developing high cIMT in adulthood.
Details
- Title: Subtitle
- Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood
- Creators
- Markus Juonala - Turku University HospitalFeitong Wu - Menzies Research InstituteAlan Sinaiko - University of MinnesotaJessica G Woo - Cincinnati Children's Hospital Medical CenterElaine M Urbina - Cincinnati Children's Hospital Medical CenterDavid Jacobs - University of MinnesotaJulia Steinberger - University of MinnesotaRonald Prineas - Wake Forest UniversityJuha Koskinen - Heart Center, Kymenlaakso Central Hospital, Kotka, Finland;Matthew A Sabin - Royal Children's HospitalDavid P Burgner - Royal Children's HospitalTrudy L Burns - University of IowaLydia Bazzano - Tulane UniversityAlison Venn - University of TasmaniaJorma S A Viikari - Turku University HospitalNina Hutri-Kähönen - Tampere University HospitalStephen R Daniels - Children's Hospital ColoradoTerence Dwyer - The George Institute for Global HealthOlli T Raitakari - Turku University HospitalCostan G Magnussen - University of Turku
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.145(4), pp.1-9
- DOI
- 10.1542/peds.2019-2114
- PMID
- 32209701
- PMCID
- PMC7111486
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Grant note
- R01 HL121230 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363632402771
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