Journal article
Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case–control study
Leukemia research, Vol.34(2), pp.190-195
2010
DOI: 10.1016/j.leukres.2009.05.007
PMCID: PMC2815151
PMID: 19505720
Abstract
We used fluorescence in situ hybridization (FISH) assays to identify
t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study.
t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of
t(14;18)-positive cases and 57% of
t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many
t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect
t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.
Details
- Title: Subtitle
- Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: Utility of fluorescence in situ hybridization (FISH) in a case–control study
- Creators
- Cindy M Chang - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., EPS 7074, Rockville, MD 20892, USAJane C Schroeder - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAWen-Yi Huang - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USACherie H Dunphy - Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USARalph S Baric - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAAndrew F Olshan - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAKathleen C Dorsey - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAGeorgette A Dent - Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAJames R Cerhan - Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USACharles F Lynch - Department of Epidemiology, University of Iowa, Iowa City, IA, USANathaniel Rothman - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USAKenneth P Cantor - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USAAaron Blair - Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD, USA
- Resource Type
- Journal article
- Publication Details
- Leukemia research, Vol.34(2), pp.190-195
- DOI
- 10.1016/j.leukres.2009.05.007
- PMID
- 19505720
- PMCID
- PMC2815151
- NLM abbreviation
- Leuk Res
- ISSN
- 0145-2126
- eISSN
- 1873-5835
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2010
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995142102771
Metrics
10 Record Views