Journal article
Non-Muscle Invasive Papillary Urothelial Carcinoma Metastatic to the Mandible
JIM - high impact case reports, Vol.6, pp.2324709618806332-2324709618806332
10/16/2018
DOI: 10.1177/2324709618806332
PMCID: PMC6194919
PMID: 30349834
Abstract
Urothelial carcinoma, the most common histologic subtype of bladder cancer in the United States, most frequently presents as non-muscle invasive disease. Initially, therapy involves transurethral endoscopic resection and subsequent intravesical therapies with extended surveillance for high-risk disease. Even with the best treatments, recurrence and progression can occur. However, metastasis of non-muscle invasive bladder cancer to distant sites without evidence of progression or regional metastasis is rare. In this article, we present the case of a patient with high-grade papillary urothelial carcinoma who developed an unusual metastasis to the mandible, confirmed by GATA-3 immunostaining, over 4 years after initial transurethral resection. Prior to the development of metastatic disease, this patient had no evidence of local recurrence during maintenance Bacillus Calmette-Guerin intravesical therapy and concurrent surveillance. Positron emission tomographycomputed tomography taken after presentation with mandibular metastasis did not show any evidence of regional metastasis. This case highlights an unusual location for distant metastasis of urothelial carcinoma occurring in a patient without evidence of muscle invasive disease or regional metastasis. We additionally highlight the utility of GATA-3 immunostaining in identifying urothelial carcinoma histologically.
Details
- Title: Subtitle
- Non-Muscle Invasive Papillary Urothelial Carcinoma Metastatic to the Mandible
- Creators
- Noah Frydenlund - University of IowaYousef Zakharia - University of Iowa Hospitals and ClinicsRohan Garje - University of Iowa Hospitals and ClinicsLaila Dahmoush - University of Iowa Hospitals and ClinicsMichael A. O'Donnell - Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- JIM - high impact case reports, Vol.6, pp.2324709618806332-2324709618806332
- DOI
- 10.1177/2324709618806332
- PMID
- 30349834
- PMCID
- PMC6194919
- NLM abbreviation
- J Investig Med High Impact Case Rep
- ISSN
- 2324-7096
- eISSN
- 2324-7096
- Publisher
- Sage
- Number of pages
- 4
- Grant note
- P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30 CA086862 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/16/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Urology; Internal Medicine
- Record Identifier
- 9984320077102771
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