Journal article
Non-NMDA receptor antagonist-induced drinking in rat
Brain research, Vol.808(1), pp.124-127
1998
DOI: 10.1016/S0006-8993(98)00761-6
PMID: 9795183
Abstract
Glutamate has been implicated in the central control of mechanisms that maintain body fluid homeostasis. The present studies demonstrate that intracerebroventricular (i.c.v.) injections of the non-
N-methyl-
d-aspartate (NMDA) receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3 dione (CNQX) induce drinking in rats. The dipsogenic effect of i.c.v. DNQX was antagonized by the non-NMDA receptor agonist α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). The water intake induced by DNQX was also blocked by pretreatment with a NMDA receptor antagonist, MK-801, but not by angiotensin type 1 (AT
1) or acetylcholine muscarinic receptor antagonists (losartan and atropine). The results indicate that non-NMDA receptors may exert a tonic inhibitory effect within brain circuits that control dipsogenic activity and that functional integrity of NMDA receptors may be required for the non-NMDA receptor antagonists to induce water intake.
Details
- Title: Subtitle
- Non-NMDA receptor antagonist-induced drinking in rat
- Creators
- Zhice XuAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.808(1), pp.124-127
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(98)00761-6
- PMID
- 9795183
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1998
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214758402771
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