Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite

Juliana I. F DE GOBBI; Terry G Beltz; Ralph F Johnson; José VANDERLEI MENANI; Robert L Thunhorst; Alan Kim Johnson

doi:10.1016/j.brainres.2009.08.094

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Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite

Journal article

Peer reviewed

Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite

Juliana I. F DE GOBBI, Terry G Beltz, Ralph F Johnson, José VANDERLEI MENANI, Robert L Thunhorst and Alan Kim Johnson

Brain research, Vol.1301, pp.44-51

2009

DOI: 10.1016/j.brainres.2009.08.094

PMCID: PMC2806818

PMID: 19747457

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https://www.ncbi.nlm.nih.gov/pmc/articles/2806818View

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Abstract

Glutamatergic mechanisms have been implicated in the control of fluid ingestion. In the present study, we investigated whether non-N-methyl-d-aspartate (NMDA) glutamatergic receptors in the lateral parabrachial nucleus (LPBN) are involved in the control of water and sodium intake. Male Sprague-Dawley rats had cannulas implanted bilaterally into the LPBN. They were acutely depleted of water and sodium by injections of the diuretic furosemide (Furo; 10 mg/kg, bw) and given a low dose of the angiotensin-converting enzyme inhibitor, captopril (Cap; 5 mg/kg, bw). Bilateral LPBN injections of the non-NMDA receptor antagonist DNQX (2 and 5 nmol/0.2 μl) increased the ingestion of 0.3 M NaCl and water of Furo/Cap treated rats. The increased ingestion produced by DNQX was abolished by pretreating the LPBN with α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), a non-NMDA receptor agonist. AMPA injected alone into the LPBN reduced water and 0.3 M NaCl intake. Injections of DNQX (5 nmol/0.2 μl) into the LPBN also produced ingestion of 0.3 M NaCl after sc injections of the β-adrenoceptor agonist, isoproterenol, a hypotensive drug that typically produces only water intake. Food intake, arterial blood pressure and heart rate were not altered by DNQX LPBN injections. We conclude that agonists acting on non-NMDA receptors in the LPBN exert an inhibitory influence on sodium intake during acute fluid depletion with hypotension and after isoproterenol treatment. A possible interaction of serotonin with glutamate within the LPBN is discussed. © 2009 Elsevier B.V. All rights reserved.

Biological and medical sciences

Feeding. Feeding behavior

Fundamental and applied biological sciences. Psychology

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Details

Title: Subtitle: Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite
Creators: Juliana I. F DE GOBBI - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
Terry G Beltz - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
Ralph F Johnson - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
José VANDERLEI MENANI - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
Robert L Thunhorst - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
Alan Kim Johnson - Departments of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, University of Iowa, United States
Resource Type: Journal article
Publication Details: Brain research, Vol.1301, pp.44-51
DOI: 10.1016/j.brainres.2009.08.094
PMID: 19747457
PMCID: PMC2806818
NLM abbreviation: Brain Res
ISSN: 0006-8993
eISSN: 1872-6240
Publisher: Elsevier
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: MH-59239
Language: English
Date published: 2009
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984213421402771

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