Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Tomas Kovarnik; Stepan Jerabek; Zhi Chen; Andreas Wahle; Ling Zhang; Gabriela Dostalova; Hana Skalicka; Ales Kral; Jan Horak; Milan Sonka; Ales Linhart

doi:10.5603/KP.a2016.0062

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Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Journal article

Peer reviewed

Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Tomas Kovarnik, Stepan Jerabek, Zhi Chen, Andreas Wahle, Ling Zhang, Gabriela Dostalova, Hana Skalicka, Ales Kral, Jan Horak, Milan Sonka, …

Kardiologia polska, Vol.74(12), pp.1485-1491

2016

DOI: 10.5603/KP.a2016.0062

PMCID: PMC5503116

PMID: 27160175

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Abstract

To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). Endothelial dysfunction was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5 mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for "no lesion" to 5 for "thin cap fibroatheroma; TCFA"). IVUS-VH data were collected from 41 patients suitable for three-dimensional analysis. Patients with ED exhibited larger plaque burden than those without ED (0.46 ± 0.08 vs. 0.39 ± 0.07, p = 0.014), smaller lumen area (8.59 ± 2.19 vs. 11.90 ± 3.50, p = 0.016), higher plaque risk score (2.82 ± 1.18 vs. 1.84 ± 0.90, p = 0.012), and higher number of TCFA frames (0.36 ± 0.22 vs. 0.22 ± 0.16, p = 0.038). Relative amounts of fibrous tissue correlated positively with RHI (p = 0.034, r = 0.33). The numbers of fibroatheromas and calcified plaques correlated with RHI inversely (r = -0.34, p = 0.031 and r = -0.32, p = 0.044, respectively). Endothelial dysfunction correlates with severity and phenotype of coronary lesions and can contribute to non-invasive detection of individuals with higher risk of cardiovascular events.

Aged

Clinical Trials as Topic

Coronary Artery Disease - diagnostic imaging

Coronary Artery Disease - pathology

Endothelium - diagnostic imaging

Endothelium - pathology

Humans

Hyperemia

Middle Aged

Severity of Illness Index

Ultrasonography, Interventional

Details

Title: Subtitle: Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype
Creators: Tomas Kovarnik - Charles University
Stepan Jerabek - Charles University
Zhi Chen - University of Iowa
Andreas Wahle - University of Iowa
Ling Zhang - University of Iowa
Gabriela Dostalova - Charles University
Hana Skalicka - Charles University
Ales Kral - Charles University
Jan Horak - Charles University
Milan Sonka - University of Iowa
Ales Linhart - Charles University
Resource Type: Journal article
Publication Details: Kardiologia polska, Vol.74(12), pp.1485-1491
DOI: 10.5603/KP.a2016.0062
PMID: 27160175
PMCID: PMC5503116
NLM abbreviation: Kardiol Pol
ISSN: 0022-9032
eISSN: 1897-4279
Grant note: R01 EB004640 / NIBIB NIH HHS R01 HL063373 / NHLBI NIH HHS
Language: English
Date published: 2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984186597802771

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