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Non-muscle-invasive bladder cancer: Intravesical treatments beyond Bacille Calmette-Guerin
Journal article   Open access   Peer reviewed

Non-muscle-invasive bladder cancer: Intravesical treatments beyond Bacille Calmette-Guerin

Vignesh T. Packiam, Scott C. Johnson and Gary D. Steinberg
Cancer, Vol.123(3), pp.390-400
02/01/2017
DOI: 10.1002/cncr.30392
PMID: 28112819
url
https://doi.org/10.1002/cncr.30392View
Published (Version of record) Open Access

Abstract

An unmet need exists for patients with high-risk non-muscle-invasive bladder cancer for whom bacille Calmette-Guerin (BCG) has failed and who seek further bladder-sparing approaches. This shortcoming poses difficult management dilemmas. This review explores previously investigated first-line intravesical therapies and discusses emerging second-line treatments for the heterogeneous group of patients for whom BCG has failed. The myriad of recently published and ongoing trials assessing novel salvage intravesical treatments offer promise to patients who both seek an effective cure and want to avoid radical surgery. However, these trials must carefully be contextualized by specific patient, tumor, and recurrence characteristics. As data continue to accumulate, there will potentially be a role for these agents as second-line or even first-line intravesical therapies. Cancer 2017;123:390-400. (c) 2016 American Cancer Society. An unmet need continues to exist for patients with high-risk non-muscle-invasive bladder cancer for whom Bacille Calmette-Guerin has failed and who seek further bladder-sparing approaches. This review explores the role of emerging intravesical therapies.
 Life Sciences & Biomedicine Oncology Science & Technology

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