Journal article
Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene
Journal of medical genetics, Vol.26(11), pp.676-681
11/01/1989
DOI: 10.1136/jmg.26.11.676
PMCID: PMC1015737
PMID: 2531224
Abstract
Analysis of many families with linked DNA markers has provided support for the Huntington's disease (HD) gene being close to the telomere on the short arm of chromosome 4. However, analysis of recombination events in particular families has provided conflicting results about the precise location of the HD gene relative to these closely linked DNA markers. Here we report an investigation of linkage disequilibrium between six DNA markers and the HD gene in 75 separate families of varied ancestry. We show significant non-random association between alleles detected at D4S95 and D4S98 and the mutant gene. These data suggest that it may be possible to construct high and low risk haplotypes, which may be helpful in DNA analysis and genetic counselling for HD, and represent independent evidence that the gene for HD is centromeric to more distally located DNA markers such as D4S90. This information may be helpful in defining a strategy to clone the gene for HD based on its location in the human genome.
Details
- Title: Subtitle
- Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene
- Creators
- J. Theilm Ann - University of British ColumbiaS. Kanani - University of British ColumbiaR. Shiang - University of British ColumbiaC. Robbins - University of British ColumbiaO. Quarrell - University of British ColumbiaM. Huggins - University of British ColumbiaA. Hedrick - University of British ColumbiaB. Weber - University of British ColumbiaC. Collins - University of British ColumbiaJ. J. Wasmuth - University of British ColumbiaK. H. Buetow - Division of Population Science, Fox Chase Cancer Centre, United StatesJ. C. Murray - Department of Pediatrics, University of Iowa, United StatesM. R. Hayden - University of British Columbia
- Resource Type
- Journal article
- Publication Details
- Journal of medical genetics, Vol.26(11), pp.676-681
- DOI
- 10.1136/jmg.26.11.676
- PMID
- 2531224
- PMCID
- PMC1015737
- NLM abbreviation
- J Med Genet
- ISSN
- 0022-2593
- eISSN
- 1468-6244
- Number of pages
- 6
- Grant note
- T32GM007091 / National Institute of General Medical Sciences (http://data.elsevier.com/vocabulary/SciValFunders/100000057) National Institute of General Medical Sciences (http://data.elsevier.com/vocabulary/SciValFunders/100000057)
- Language
- English
- Date published
- 11/01/1989
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9985034982402771
Metrics
3 Record Views