Journal article
Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink
Cancer causes & control, Vol.24(11), pp.2027-2034
11/2013
DOI: 10.1007/s10552-013-0279-9
PMID: 23990380
Abstract
The aetiology of primary brain tumours is largely unknown; the role of non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin use and glioma risk has been inconclusive, but few population-based studies with reliable prescribing data have been conducted, and the association with meningioma risk has yet to be assessed.
The UK Clinical Practice Research Datalink was used to assess the association between aspirin and non-aspirin NSAID use and primary brain tumour risk using a nested case-control study design. Conditional logistic regression analysis was performed on 5,052 brain tumour patients aged 16 years and over, diagnosed between 1987 and 2009 and 42,678 controls matched on year of birth, gender and general practice, adjusting for history of allergy and hormone replacement therapy use in the glioma and meningioma models, respectively.
In conditional logistic regression analysis, excluding drug use in the year preceding the index date, there was no association with non-aspirin NSAID use (OR 0.96, 95 % CI 0.81-1.13) or glioma risk comparing the highest category of daily defined dose to non-users; however, non-aspirin NSAID use was positively associated with meningioma risk (OR 1.35, 95 % CI 1.06-1.71). No association was seen with high- or low-dose aspirin use irrespective of histology.
This large nested case-control study finds no association between aspirin or non-aspirin NSAID use and risk of glioma but a slight increased risk with non-aspirin NSAIDs and meningioma.
Details
- Title: Subtitle
- Non-steroidal anti-inflammatory drug use and brain tumour risk: a case-control study within the Clinical Practice Research Datalink
- Creators
- F J Bannon - Northern Ireland Cancer Registry, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK, f.j.bannon@qub.ac.ukM A O'RorkeL J MurrayC M HughesA T GavinS J FlemingC R Cardwell
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.24(11), pp.2027-2034
- Publisher
- Netherlands
- DOI
- 10.1007/s10552-013-0279-9
- PMID
- 23990380
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Grant note
- MR/K023241/1 / Medical Research Council Medical Research Council
- Language
- English
- Date published
- 11/2013
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9983995130502771
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