Non-steroidal anti-inflammatory drug use and cervical cancer risk: A case-control study using the Clinical Practice Research Datalink

J.C Wilson; M.A O’Rorke; J.A Cooper; L.J Murray; C.M Hughes; G.J Gormley; L.A Anderson

doi:10.1016/j.canep.2013.08.010

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Non-steroidal anti-inflammatory drug use and cervical cancer risk: A case-control study using the Clinical Practice Research Datalink

Journal article

Peer reviewed

Non-steroidal anti-inflammatory drug use and cervical cancer risk: A case-control study using the Clinical Practice Research Datalink

J.C Wilson, M.A O’Rorke, J.A Cooper, L.J Murray, C.M Hughes, G.J Gormley and L.A Anderson

Cancer epidemiology, Vol.37(6), pp.897-904

12/2013

DOI: 10.1016/j.canep.2013.08.010

PMID: 24042024

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Abstract

Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) have many anticarcinogenic properties via the inhibition of cyclooxygenase 2 (COX-2). Only one study, a cohort study examining risk of all cancers, investigated their role in cervical cancer with inconsistent findings between non-aspirin NSAIDs and aspirin. The aim of this study was to further investigate NSAID/aspirin use and cervical cancer risk. Methods: Using the United Kingdom Clinical Practice Research Datalink, 724 women diagnosed with cervical cancer between 1 January, 1995 and December 2010 were compared to 3479 women (without cervical cancer) matched on year of birth and general practice. Conditional logistic regression analysis adjusted for smoking, sexually transmitted infections, HRT and contraceptive use, was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for cervical cancer risk among users of any oral NSAIDs, non-aspirin NSAIDs and aspirin, as assessed from primary care prescribing data. Results: Excluding the year prior to diagnosis, there was no association in adjusted analyses between ever vs. never use of an NSAID (OR 0.92, 95% CI 0.77–1.09), non-aspirin NSAID (OR 0.95, 95% CI 0.80–1.13) or low-dose aspirin (OR 1.07, 0.80–1.44) and cervical cancer risk. In analysis of daily defined doses, there was no association with cervical cancer risk comparing the highest users to non-users of NSAIDs (OR 0.98, 95% CI 0.69–1.39) or non-aspirin NSAIDs (OR 1.00, 95% CI 0.70–1.43) or low-dose aspirin (OR 1.04, 95% CI 0.59–1.81). Conclusion: This large historical cohort study found no evidence of an association between non-aspirin NSAID or aspirin use and cervical cancer risk.

Uterine cervical neoplasms

Aspirin

Anti-inflammatory agents

Non-steroidal

Details

Title: Subtitle: Non-steroidal anti-inflammatory drug use and cervical cancer risk: A case-control study using the Clinical Practice Research Datalink
Creators: J.C Wilson - Queen's University Belfast
M.A O’Rorke - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, UK
J.A Cooper - Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, UK
L.J Murray - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, UK
C.M Hughes - Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, UK
G.J Gormley - Department of General Practice, Queen's University Belfast, Dunluce Health Centre, Belfast, UK
L.A Anderson - Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, UK
Resource Type: Journal article
Publication Details: Cancer epidemiology, Vol.37(6), pp.897-904
DOI: 10.1016/j.canep.2013.08.010
PMID: 24042024
NLM abbreviation: Cancer Epidemiol
ISSN: 1877-7821
eISSN: 1877-783X
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/501100000265, name: Medical Research Council's; name: Department for Employment and Learning (DEL); name: Centre for Health Improvement, Queen's University Belfast
Language: English
Date published: 12/2013
Academic Unit: Epidemiology; Pathology
Record Identifier: 9983995006302771

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