Journal article
Noncytotoxic-Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review
Journal of pediatric & adolescent gynecology, Vol.31(6), pp.597-604
12/2018
DOI: 10.1016/j.jpag.2018.06.006
PMCID: PMC6620114
PMID: 29940314
Abstract
Primary ovarian insufficiency (POI) in adolescents not due to cytotoxic therapy has not been well studied. Causes of POI have been described in adults, but adolescents might represent a unique subset necessitating a targeted approach to diagnosis, workup, and treatment. We sought to better characterize adolescent POI through a descriptive multicenter study.
Case series of patients with POI.
Six tertiary care institutions.
Patients presenting from 2007 to 2014 aged 13-21 years diagnosed with noncytotoxic POI, with exclusions for those who received gonadotoxic therapy, with 46XY gonadal dysgenesis, or lack of evidence of hypergonadotropic hypogonadism on chart review.
Review and data extraction of records identified according to International Classification of Diseases Ninth or Tenth Revision codes.
Data were analyzed for signs and symptoms, workup, and treatments. Complete workup was on the basis of American College of Obstetricians and Gynecologists guidelines. Characteristics of patients with POI who presented with delayed puberty/primary amenorrhea vs secondary amenorrhea were compared.
One hundred thirty-five records were identified. Those who had received cytotoxic therapy (n = 52), 46XY gonadal dysgenesis (n = 7), or on review did not have POI (n = 19) were excluded. Of 57 remaining cases, 16 were 45X, 2 had galactosemia, and 4 had X-chromosome abnormalities. Most did not undergo full etiologic evaluation. Girls diagnosed after primary amenorrhea/delayed puberty were less symptomatic and more likely to receive an estrogen patch than those diagnosed after secondary amenorrhea.
Noncytotoxic POI in adolescents is an uncommon condition with, to our knowledge, only 64 cases in 6 institutions over 7 years. These patients might not undergo complete etiological workup. Aside from 45X, the most common etiologies were X-chromosome abnormalities or galactosemia.
Details
- Title: Subtitle
- Noncytotoxic-Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review
- Creators
- Lauren Kanner - Department of Pediatrics, Division of Pediatric Endocrinology, University of Wisconsin, Madison, WisconsinJulie C.E Hakim - Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN and Pediatrics, Baylor College of Medicine, Houston, TexasChristina Davis Kankanamge - Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN & Pediatrics, Truman Medical Center Hospital Hill, University of Missouri, Kansas City, MissouriVrunda Patel - Medstar Health, Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN and Pediatrics, Washington, DCVivian Yu - Georgetown University School of Medicine, Washington, DCEmily Podany - Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN and Pediatrics, Baylor College of Medicine, Houston, TexasVeronica Gomez-Lobo - Medstar Health, Division of Pediatric and Adolescent Gynecology, Departments of OB/GYN and Pediatrics, Washington, DC
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric & adolescent gynecology, Vol.31(6), pp.597-604
- DOI
- 10.1016/j.jpag.2018.06.006
- PMID
- 29940314
- PMCID
- PMC6620114
- NLM abbreviation
- J Pediatr Adolesc Gynecol
- ISSN
- 1083-3188
- eISSN
- 1873-4332
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 12/2018
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics
- Record Identifier
- 9984093212702771
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