Journal article
Nondementia Nonpraecox Dementia Praecox?: Late-Onset Schizophrenia
The American journal of geriatric psychiatry, Vol.5(4), pp.302-317
1997
DOI: 10.1097/00019442-199700540-00005
PMID: 9363287
Abstract
Schizophrenia has traditionally been viewed as a psychotic disorder with onset in adolescence or early adulthood and a deteriorating course. Over the past decade, the authors have been studying patients meeting DSM-III-R as well as specified research criteria for late-onset schizophrenia (onset after age 45) and several comparison groups with psychiatric, neurologic, neuropsychologic, brain-imaging, psychophysiological, and psychosocial assessments. Results to date suggest a number of similarities and differences between late-onset schizophrenia and comparison groups of other older patients with psychoses (including earlier-onset schizophrenia). Later-onset schizophrenia is probably a neurobiologically distinct subtype of schizophrenia. Differential involvement of cortico-striato-pallido-thalamic circuitry may explain differences in age at onset. The authors propose a new conceptual model for level of functioning at different stages of life in late-onset schizophrenia.
Details
- Title: Subtitle
- Nondementia Nonpraecox Dementia Praecox?: Late-Onset Schizophrenia
- Creators
- Dilip V JesteLaura L SymondsM. Jackuelyn HarrisJane S PaulsenBarton W PalmerRobert K Heaton
- Resource Type
- Journal article
- Publication Details
- The American journal of geriatric psychiatry, Vol.5(4), pp.302-317
- Publisher
- Elsevier Inc
- DOI
- 10.1097/00019442-199700540-00005
- PMID
- 9363287
- ISSN
- 1064-7481
- eISSN
- 1545-7214
- Grant note
- grants MH49671, MH45131, and MH43693; / National Institute of Mental Health
- Language
- English
- Date published
- 1997
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083809602771
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