Journal article
Nonendemic Adult T-Cell Leukemia/Lymphoma in the United States: Report of Two Cases and Review of the Literature
American journal of clinical pathology, Vol.83(1), pp.18-26
01/01/1985
DOI: 10.1093/ajcp/83.1.18
PMID: 2981466
Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a recently described distinct clinicopathologic entity characterized by a leukemic or lymphomatous proliferation of hyperlobulated peripheral T-cells, which is usually widespread at presentation and is associated with infection by a type C retrovirus. ATLL rarely is described outside of endemic regions, which include southwestern Japan, the Caribbean region, and the southeastern United States. The authors report the clinical, pathologic, and immunologic features of two cases of nonendemic ATLL that occurred in patients from the midwest United States. One patient was a 16-year-old white girl from rural Iowa, and the other was a 46-year-old white man from rural Minnesota. The features of 13 other probable nonendemic ATLL cases from the United States were compiled and reviewed. In the United States, nonendemic ATLL occurred in widespread geographic locations, affected mostly white people, and was characterized by an aggressive course with generalized adenopathy, blood and bone marrow involvement, and hepatosplenomegaly at presentation. Skin involvement was present in one-fourth of the patients. Hypercalcemia was rare. Although antibodies to type C retrovirus were detected in three of the five patients tested, the available data is not sufficient to establish a conclusive association between nonendemic ATLL and type C retrovirus infection.
Details
- Title: Subtitle
- Nonendemic Adult T-Cell Leukemia/Lymphoma in the United States: Report of Two Cases and Review of the Literature
- Creators
- Kathy Foucar - Hennepin CountyThomas J Carroll - Hennepin CountyRaymond Tannous - Hennepin CountyLoann Peterson - Hennepin CountyJames A Goeken - Hennepin CountySteve Binion - Hennepin CountyJ Gajl-Peczalska - Hennepin CountyMarshall E Kadin - Hennepin CountyWayne M Yokoyama - Hennepin County
- Resource Type
- Journal article
- Publication Details
- American journal of clinical pathology, Vol.83(1), pp.18-26
- DOI
- 10.1093/ajcp/83.1.18
- PMID
- 2981466
- ISSN
- 0002-9173
- eISSN
- 1943-7722
- Language
- English
- Date published
- 01/01/1985
- Academic Unit
- Stead Family Department of Pediatrics; Pathology
- Record Identifier
- 9984204115202771
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