Nongenetic risk factors and congenital heart defects

Sonali S Patel; Trudy L Burns

doi:10.1007/s00246-013-0775-4

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Nongenetic risk factors and congenital heart defects

Journal article

Peer reviewed

Nongenetic risk factors and congenital heart defects

Sonali S Patel and Trudy L Burns

Pediatric cardiology, Vol.34(7), pp.1535-1555

10/2013

DOI: 10.1007/s00246-013-0775-4

PMID: 23963188

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Abstract

Advances have been made in identifying genetic etiologies of congenital heart defects. Through this knowledge, preventive strategies have been designed and instituted, and prospective parents are counseled regarding their risk of having an affected child. Great strides have been made in genetic variant identification, and genetic susceptibility to environmental exposures has been hypothesized as an etiology for congenital heart defects. Unfortunately, similar advances in understanding have not been made regarding strategies to prevent nongenetic risk factors. Less information is available regarding the potential adverse effect of modifiable risk factors on the fetal heart. This review summarizes the available literature on these modifiable exposures that may alter the risk for congenital heart disease. Information regarding paternal characteristics and conditions, maternal therapeutic drug exposures, parental nontherapeutic drug exposures, and parental environmental exposures are presented. Factors are presented in terms of risk for congenital heart defects as a group. These factors also are broken down by specific defect type. Although additional investigations are needed in this area, many of the discussed risk factors present an opportunity for prevention of potential disease.

Environmental Exposure - adverse effects

Female

Global Health

Heart Defects, Congenital - epidemiology

Heart Defects, Congenital - etiology

Heart Defects, Congenital - genetics

Humans

Incidence

Infant

Infant, Newborn

Maternal Exposure - adverse effects

Risk Factors

Details

Title: Subtitle: Nongenetic risk factors and congenital heart defects
Creators: Sonali S Patel - University of Iowa
Trudy L Burns - University of Iowa
Resource Type: Journal article
Publication Details: Pediatric cardiology, Vol.34(7), pp.1535-1555
DOI: 10.1007/s00246-013-0775-4
PMID: 23963188
ISSN: 0172-0643
eISSN: 1432-1971
Grant note: P30 ES005605 / NIEHS NIH HHS
Language: English
Date published: 10/2013
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984364444102771

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