Journal article
Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging
Transplantation, Vol.82(5), pp.621-628
09/15/2006
DOI: 10.1097/01.tp.0000234815.23630.4a
PMID: 16969284
Abstract
Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) is a noninvasive method to assess tissue oxygen bioavailability, using deoxyhemoglobin as an endogenous contrast agent. We hypothesized that BOLD-MRI could accurately discriminate different types of rejection early after kidney transplantation.
Twenty-three patients underwent imaging in the first four months posttransplant. Five had normal functioning transplants and 18 had biopsy-proven acute allograft dysfunction (acute tubular necrosis [ATN, n=5] and acute rejection [n=13] including borderline rejection: n=3; IA rejection: n=4; IIA rejection: n=6: C4d(+) rejection: n=9).
Mean medullary R2* (MR2*) levels (a measure directly proportional to tissue deoxyhemoglobin levels) were significantly higher in normal functioning allografts (R2*=24.3/s+/-2.3) versus acute rejection (R2*=16.6/s+/-2.1) and ATN (R2*=20.9/s+/-1.8) (P<0.05). The lowest MR2* levels were observed in acute rejection episodes with vascular injury i.e. IIA and C4d (+). Similarly, the lowest medullary to cortical R2* ratios (MCR2*) were present in allografts with IIA (1.24+/-0.05) and C4d(+) rejection (1.26+/-0.06). ROC curve analyses suggested that MR2* and MCR2* values could accurately discriminate acute rejection in the early posttransplant period.
BOLD-MRI demonstrated significant changes in medullary oxygen bioavailability in allografts with biopsy-proven ATN and acute rejection, suggesting that there may be a role for this noninvasive tool to evaluate kidney function early after transplantation.
Details
- Title: Subtitle
- Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imaging
- Creators
- Arjang Djamali - University of Wisconsin–MadisonElizabeth A Sadowski - University of Wisconsin–MadisonMillie Samaniego-Picota - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–MadisonRebecca J Muehrer - University of Wisconsin–MadisonSara K Alford - University of Wisconsin–MadisonThomas M Grist - University of Wisconsin–MadisonBryan N Becker - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.82(5), pp.621-628
- DOI
- 10.1097/01.tp.0000234815.23630.4a
- PMID
- 16969284
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Grant note
- DK 067981-02 / NIDDK NIH HHS 5K24 DK616962-03 / NIDDK NIH HHS M01RR03186 / NCRR NIH HHS
- Language
- English
- Date published
- 09/15/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274954102771
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