Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins

Daniel Ts'o; Jesse Schallek; Young Kwon; Randy Kardon; Michael Abramoff; Peter Soliz

doi:10.1007/s10384-009-0687-2

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Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins

Journal article

Open access

Peer reviewed

Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins

Daniel Ts'o, Jesse Schallek, Young Kwon, Randy Kardon, Michael Abramoff and Peter Soliz

Japanese journal of ophthalmology, Vol.53(4), pp.334-344

07/2009

DOI: 10.1007/s10384-009-0687-2

PMCID: PMC5180604

PMID: 19763750

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http://dspace.library.uu.nl:8080/handle/1874/204599View

Open Access

Abstract

We have adapted intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of the retina. Results to date demonstrate the feasibility and potential of this new method of functional assessment of the retina. In response to visual stimuli, we have imaged reflectance changes in the retina that are robust and spatially colocalized to the sites of stimulation. However, the technique is in its infancy and many questions as to the underlying mechanisms remain. In particular, the source and nature of the activity-dependent intrinsic optical signals in the retina need to be characterized and their anatomic origins determined. The studies described here begin to address these issues. The evidence indicates that the imaged signals are driven by the outer retinal layers and have a dominant hemodynamic component.

Electroretinography

Cats

Tomography, Optical Coherence

Diagnostic Imaging - instrumentation

Glaucoma, Open-Angle - physiopathology

Macaca fascicularis

Hemodynamics - physiology

Pattern Recognition, Visual - physiology

Retinal Vessels - physiology

Diagnostic Imaging - methods

Retina - physiology

Animals

Photic Stimulation

Disease Models, Animal

Details

Title: Subtitle: Noninvasive functional imaging of the retina reveals outer retinal and hemodynamic intrinsic optical signal origins
Creators: Daniel Ts'o - Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA. dan@tsolab.org
Jesse Schallek
Young Kwon
Randy Kardon
Michael Abramoff
Peter Soliz
Resource Type: Journal article
Publication Details: Japanese journal of ophthalmology, Vol.53(4), pp.334-344
DOI: 10.1007/s10384-009-0687-2
PMID: 19763750
PMCID: PMC5180604
NLM abbreviation: Jpn J Ophthalmol
ISSN: 0021-5155
eISSN: 1613-2246
Publisher: Japan
Grant note: R01 EB002843 / NIBIB NIH HHS EB002843 / NIBIB NIH HHS EY12915 / NEI NIH HHS
Language: English
Date published: 07/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983806260302771

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