Nonmelanoma Skin Cancer in the Setting of Erosive Pustular Dermatosis of the Scalp: A Case Series and Comment on Management Implications

Nicole A Negbenebor; Leila H Shayegan; Lisa M Cohen; George Kroumpouzos

doi:10.1111/dth.15584

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Nonmelanoma Skin Cancer in the Setting of Erosive Pustular Dermatosis of the Scalp: A Case Series and Comment on Management Implications

Journal article

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Nonmelanoma Skin Cancer in the Setting of Erosive Pustular Dermatosis of the Scalp: A Case Series and Comment on Management Implications

Nicole A Negbenebor, Leila H Shayegan, Lisa M Cohen and George Kroumpouzos

Dermatologic therapy, Vol.35(7), pp.e15584-n/a

07/2022

DOI: 10.1111/dth.15584

PMID: 35569130

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Abstract

Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory cutaneous disorder typically affecting sun-damaged skin of mature individuals. Clinical features of EPDS include sterile pustules and chronic crusted erosions that can be hyperkeratotic and lead to scarring alopecia, atrophy, and telangiectasia. While the condition occurs on sun-damaged skin, a relationship with non-melanoma skin cancer (NMSC) has not been investigated. Here we attempted to identify cases of NMSC developing in the setting of EPDS. Retrospective review of EPDS cases in a dermatology practice. Six patients with mean (range) age 82 (65-92) years that developed NMSC in the setting of EPDS are reported. Five patients had skin phototype I or II associated with substantial solar elastosis. Four patients had history of NMSC. Four patients developed squamous cell carcinoma and two patients basal cell carcinoma on the scalp in the setting of EPDS. A morphologic change in an EPDS lesion, such as a crusted plaque becoming nodular and/or growing significantly within a relatively short period of time, prompted a biopsy that revealed NMSC. NMSC may develop in the setting of EPDS. Possible mechanisms underlying this association include the chronic inflammation associated with EPDS and ultraviolet light exposure. It is crucial to promptly obtain a biopsy in EPDS cases showing signs suspicious for NMSC. Further studies are required to confirm whether NMSC shows a higher prevalence in the setting of EPDS. This article is protected by copyright. All rights reserved.

nonmelanoma skin cancer

basal cell carcinoma

erosive pustular dermatosis

inflammation

management

squamous cell carcinoma

Details

Title: Subtitle: Nonmelanoma Skin Cancer in the Setting of Erosive Pustular Dermatosis of the Scalp: A Case Series and Comment on Management Implications
Creators: Nicole A Negbenebor - Brown University
Leila H Shayegan - Brown University
Lisa M Cohen - Dermatopathology Section, StrataDx, Lexington, Massachusetts, USA
George Kroumpouzos - Brown University
Resource Type: Journal article
Publication Details: Dermatologic therapy, Vol.35(7), pp.e15584-n/a
DOI: 10.1111/dth.15584
PMID: 35569130
NLM abbreviation: Dermatol Ther
ISSN: 1396-0296
eISSN: 1529-8019
Language: English
Date published: 07/2022
Academic Unit: Dermatology
Record Identifier: 9984656537502771

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