Journal article
Nonsecretory IgA1 autoantibodies targeting desmosomal component desmoglein 3 in intraepidermal neutrophilic IgA dermatosis
The American journal of pathology, Vol.150(6), pp.1901-1907
06/1997
PMCID: PMC1858303
PMID: 9176383
Abstract
Intraepidermal neutrophilic IgA dermatosis, a rare skin disease entity manifested with blisters and pustules clinically and lower epidermal blister, acantholysis, and neutrophilic infiltration pathologically, was first reported in 1985. Although the disease is characterized by IgA autoantibodies targeting the epithelial cell surface component, the target antigen has not been determined. We investigated a patient with this disease by histopathology, direct and indirect immunofluorescence, immunoblotting, and immunoadsorption studies. The pustular lesion was characterized by blister at the lower epidermis, acantholysis, and neutrophilic infiltration. Nonsecretory IgA1 subclass autoantibodies targeting the lower epithelial cell surfaces were detected in the patient's skin and serum. The patient's IgA autoantibodies labeled a recombinant desmosomal protein desmoglein 3 on immunoblotting and the immunolabeling of epithelial cell surfaces was eliminated by preadsorption with desmoglein 3. Thus, desmoglein 3 is identified as a target antigen in intraepidermal neutrophilic IgA dermatosis. The ability of IgA1 autoantibodies to bind neutrophils may be responsible for the prominent neutrophilic infiltration observed histopathologically and for the pustular lesions observed clinically.
Details
- Title: Subtitle
- Nonsecretory IgA1 autoantibodies targeting desmosomal component desmoglein 3 in intraepidermal neutrophilic IgA dermatosis
- Creators
- Jining Wang - Department of Dermatology, Northwestern Univesity Medical School, Chicago, Illinois, USAJohn KwonXiang DingJ A FairleyD T WoodleyLawrence S Chan
- Resource Type
- Journal article
- Publication Details
- The American journal of pathology, Vol.150(6), pp.1901-1907
- Publisher
- United States
- PMID
- 9176383
- PMCID
- PMC1858303
- ISSN
- 0002-9440
- eISSN
- 1525-2191
- Language
- English
- Date published
- 06/1997
- Academic Unit
- Dermatology
- Record Identifier
- 9984025574202771
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