Nonsteroidal antiinflammatory drug use among women and the risk of birth defects

Rohini K Hernandez; Martha M Werler; Paul Romitti; Lixian Sun; Marlene Anderka; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2011.11.019

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Nonsteroidal antiinflammatory drug use among women and the risk of birth defects

Journal article

Open access

Peer reviewed

Nonsteroidal antiinflammatory drug use among women and the risk of birth defects

Rohini K Hernandez, Martha M Werler, Paul Romitti, Lixian Sun, Marlene Anderka and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.206(3), pp.228.e1-228.e8

03/2012

DOI: 10.1016/j.ajog.2011.11.019

PMCID: PMC5893141

PMID: 22196851

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Abstract

We examined whether the use of nonsteroidal antiinflammatory drugs (NSAIDs) in early pregnancy was associated with a range of structural birth defects. Data were from the National Birth Defects Prevention Study, a multisite population-based, case-control study of risk factors for birth defects. Among women in the National Birth Defects Prevention Study, 22.6% reported the use of NSAIDs in the first trimester of pregnancy, most commonly ibuprofen, aspirin, and naproxen. Of the 29 defect groups that were examined, most were not associated with NSAID use. Small-to-moderate increased risks of some oral cleft groups, some neural tube defect groups, anophthalmia/microphthalmia, pulmonary valve stenosis, amniotic bands/limb body wall defects, and transverse limb deficiencies were associated with ibuprofen, aspirin, and naproxen exposure. The use of NSAIDs in early pregnancy does not appear to be a major risk factor for birth defects, although there were a few moderate associations between NSAIDs and specific birth defects.

birth defect

National Birth Defects Prevention Study

nonsteroidal antiinflammatory drug

medication in pregnancy

Details

Title: Subtitle: Nonsteroidal antiinflammatory drug use among women and the risk of birth defects
Creators: Rohini K Hernandez - Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA
Martha M Werler - Slone Epidemiology Center at Boston University, Boston, MA
Paul Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA
Lixian Sun - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA
Marlene Anderka - Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.206(3), pp.228.e1-228.e8
DOI: 10.1016/j.ajog.2011.11.019
PMID: 22196851
PMCID: PMC5893141
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: U01DD000493 / Centers for Disease Control and Prevention
Language: English
Date published: 03/2012
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995125402771

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